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Research & achievements研究・業績aaa

Research paper

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2020年度

  • 2020年度

    Modifed albumin–bilirubin grade to predict eligibility for second line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients

    International Journal of Clinical Oncology DOI 10.1007/s10147-020-01835-2

    Takayuki Tokunaga, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Takeshi Kawasaki, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Masakuni Tateyama, Hideaki Naoe, Yutaka Sasaki, Yasuhito Tanaka
    Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study.

    BMC Gastroenterol. 2020, 20, 371.

    Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Hiroko Setoyama, Yutaka Sasaki, Yasuhito Tanaka. 
    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.

    Cell Rep. 2020, 33; 108265.

    Tomoaki Inazumi, Kiyotaka Yamada, Naritoshi Shirata, Hiroyasu Sato, Yoshitaka Taketomi, Kazunori Morita, Hirofumi Hohjoh, Soken Tsuchiya, Kentaro Oniki, Takehisa Watanabe, Yutaka Sasaki, Yuichi Oike, Yasuhiro Ogata, Junji Saruwatari, Makoto Murakami, Yukihiko Sugimoto.
    Prometastatic secretome trafficking via exosomes initiates pancreatic cancer pulmonary metastasis.

    Cancer Lett. 2020 Jul 1; 481:63-75.

    Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands JR, Dong X.
    Successful treatment of occult pancreatic melanoma using BRAF/MEK inhibitors.

    J Dermatol. 2020 Apr;47(4): e126-e127.

    Mizukami Y, Kanemaru H, Nakamura K, Hashigo S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Honda Y, Ihn H.
    Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study).

    Gastrointest Endosc. 2020 Feb;91(2):373-381.

    Kurita A, Yasukawa S, Zen Y, Yoshimura K, Ogura T, Ozawa E, Okabe Y, Asada M, Nebiki H, Shigekawa M, Ikeura T, Eguchi T, Maruyama H, Ueki T, Itonaga M, Hashimoto S, Shiomi H, Minami R, Hoki N, Takenaka M, Itokawa Y, Uza N, Hashigo S, Yasuda H, Takada R, Kamada H, Kawamoto H, Kawakami H, Moriyama I, Fujita K, Matsumoto H, Hanada K, Takemura T, Yazumi S.
    Risk stratification of advanced colorectal neoplasia after baseline colonoscopy: Cohort study of 17 Japanese community practices.

    Digestive endoscopy. 2020; 32(1):106-113

    Shono T, Oyama S, Oda Y, Yokomine K, Murakami Y, Miyamoto H, Tanaka M, Naoe H, Sasaki Y, Kumamoto Colon Cancer, Study Group.
    Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis.

    Case Rep Gastroenterol. 2020;14:103–109

    Furuta Y, Miyamoto H, Naoe H, Shimoda M, Hinokuma Y, Tanaka M, Sasaki Y.
    A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.

    Diabetes Metab Syndr Obes. 2020 Feb 12; 13: 333-341

    Muto N, Oniki K, Kudo M, Obata Y, Sakamoto Y, Tokumaru N, Izuka T, Watanabe T, Otake K, Ogata Y, Saruwatari J.
    Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions.

    Sci Reports. 2020 Mar 9; 10(1): 4313

    Oniki K, Kawakami T, Nakashima A, Miyata K, Watanabe T, Fujikawa H, Nakashima R, Nasu A, Eto Y, Takahashi N, Nohara H, Suico MA, Kotani S, Obata Y, Sakamoto Y, Seguchi Y, Sarauwatari J, Imafuku T, Watanabe H, Maruyama T, Kai H, Shuto T.
    Endoscopic features of esophageal adenocarcinoma derived from short-segment versus long-segment Barrett’s esophagus.

    J Gastroenterol Hepatol 2020: 35:211–217

    Yamasaki A, Shimizu T, Kawachi H, Yoshimizu S, Horiuchi Y, Ishiyama A, Yoshio T, Hirasawa T, Tsuchida T, Sasaki Y, Fujisaki J.
    Cholangiolocarcinoma With Multiple Recurrences Successfully Treated With Repeated Liver Resection and Radiofrequency Ablation.

    Anticancer Res 40/P.7147-7153/2020

    Sato N, Yamamura K, Oda E, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Yoshii D, Komohara Y, Beppu T
    Hepatocellular Carcinoma With Extensive Cancer-associated Thrombosis Successfully Treated With Liver Resection and Direct Oral Anticoagulant: A Case Report.

    Anticancer Res 40/P.6465-6471/2020

    Yamamura K, Beppu T, Kinoshita K, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Kawaguchi H, Komohara Y, Akahoshi S
    Complete Removal of Adrenal Metastasis in Hepatocellular Carcinoma Using Indocyanine Green Fluorescent Imaging.

    Anticancer Res 40/P.5823-5828/2020

    Yamamura K, Beppu T, Sato N, Kinoshita K, Oda E, Yuki H, Motohara T, Miyamoto H, Komohara Y, Akahoshi S
    Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer

    Intern Med 59/P.2499-2504/2020

    Higashi T, Miyamoto H, Yoshida R, Furuta Y, Nagaoka K, Naoe H, Naito H, Nakayama H, Tanaka M
    Multiple Gastric Polyps Improved After Treatment for Ulcerative Colitis.

    Inflamm Bowel Dis 26/P.e144-e145/2020

    Tsuruta Y, Furuta Y, Naoe H, Tanaka M
    Hepatitis B virus reactivation in a myeloma patient with resolved infection who received daratumumab-containing salvage chemotherapy

    J Clin Exp Hematop 60/P.51-54/2020

    Kikuchi T, Kusumoto S, Tanaka Y, Oshima Y, Fujinami H, Suzuki T, Totani H, Kinoshita S, Asao Y, Narita T, Ito A, Ri M, Komatsu H, Iida S.
    Successful treatment of adult-onset type II citrullinemia with a low-carbohydrate diet and L-arginine after DNA analysis produced a definitive diagnosis

    Clin J Gastroenterol 13/P.823-833/2020

    Unita S, Hirashima N, Shimada M, Tsunekawa T, Tanaka D, Kondo T, Urata N, Kondo H, Saito M, Iwase H, Ito S, Togawa T, Saitoh S , Tanaka Y.
    HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort

    Hepatol Int 14/P.1023-1033/2020

    Tanaka Y, Ogawa E, Huang C-F, Toyoda H, Won Jun D, Tseng C-H, Hsu Y-C, Enomoto M, Takahashi H, Furusyo N, Yeh M-L, Iio E, Yasuda S, Pui-Mei Lam C, Hyun Lee D, Haga H, L Yoon E, Bong Ahn S, Wong G, Nakamuta M, Nomura H, Tsai P-C, Han Jung J, Seon Song D, Dang H, Maeda M, Henry L, Cheung R, Yuen M-F, Ueno Y, Eguchi Y, Tamori A, Yu M-L, Hayashi J, Nguyen M H, REAL-C Investigators
    Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

    Virus Res 290/P.198191-/2020

    HoqueKayesha M-E, Amakod Y, Hashema M A, Murakami S, Ogawa S, Yamamoto N, Hifumi T, Miyoshi N, Sugiyama M ,Tanaka Y, Mizokami M, Kohara M, Tsukiyama-Kohara K.
    Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture

    Int. J. Mol. Sci 21/P.7251-/2020

    Hamada-Tsutsumi S, Onishi M, Matsuura K, Isogawa M, Kawashima K, Sato Y, Tanaka Y.
    Pancreatic neuroendocrine carcinoma G3 may be heterogeneous and could be classified into two distinct groups.

    Pancreatology 20/P.1421-1427/2020

    Tanaka H, Hijioka S, Hosoda W, Ueno M, Kobayashi N, Ikeda M, Ito T, Kodama Y, Morizane C, Notohara K, Taguchi H, Kitano M, Komoto I, Tsuji A, Hashigo S, Kanno A, Miyabe K, Takagi T, Ishii H, Kojima Y, Yoshitomi H, Yanagimoto H, Furuse J, Mizuno N.
    Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus

    Hepatol Res 50/P.1128-1140/2020

    Ito K, Angata K, Kuno A, Okumura A, Sakamoto K, Inoue R, Morita N, Watashi K, Wakita T, Tanaka Y, Sugiyama M, Mizokami M, Yoneda M, Narimatsu H
    Hepatitis B surface antigen, core-related antigen and HBV RNA: Predicting clinical relapse after NA therapy discontinuation.

    Liver Int 40/P.2961-2971/2020

    Kaewdech A, Tangkijvanich P, Sripongpun P, Witeerungrot T, Jandee S, Tanaka Y, Piratvisuth T.
    Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis

    Dig Dis Sci. 66/P.1080-1089/2020

    Nagaoka K (equal 1st), Ogawa K, Ji C, Cao KY, Bai X, Mulla J, Cheng Z, Wands JR, Huang CK*.
    Baseline Mac-2 Binding Protein Glycosylation Isomer Level Stratifies Risks of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Oral Antiviral Therapy

    Liver Cancer 9/P.207-220/2020

    Tseng T.-C, Peng C.-Y, Hsu Y.-C, Su T.-H, Wang C.-C, Liu C.-J, Yang H.-C., Yang W.-T, Lin C.-H, Yu M.-L, Lai H.-C , Tanaka Y, Nguyen M.H , Liu C.-H , Chen P.-J , Chen D.-S , Kao J.-H.
    The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism

    Liver Research 4/P.94-100/2020

    Nagaoka, K , Mulla, J, Cao, K, Cheng, Z, Liu, D, William Muellera, Bay, A, Hildebrand, G, Lu, S, Huang, CK*.
    Ultra-high sensitivity HBsAg assay can diagnose HBV reactivation
    following rituximab-based therapy in patients with lymphoma

    J Hepatol 73/P.285-293/2020

    Kusumoto S, Tanaka Y (equal 1st), Suzuki R, Watanabe T, Nakata M, Sakai R, Fukushima N, Fukushima T, Moriuchi Y, Itoh K, Nosaka K, Choi I, Sawa M, Okamoto R, Tsujimura H, Uchida T, Suzuki S, Okamoto M, Takahashi T, Sugiura I, Onishi 0, Kohri M, Yoshida S, Kojima M, Takahashi H, Tomita A, Atsuta Y, Maruyama D, Tanaka E, Suzuki T, Kinoshita T, Ogura M, Ueda R, Mizokami M.
    Fluorescence-based biochemical analysis of human hepatitis B virus reverse transcriptase activity

    Anal Biochem 597/P.113642-/2020

    ToyodaT, Wang Y, Wen Y, Tanaka Y.
    The effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients with refractory factors in the real world:

    Hepatol Int 14/P.225-238/2020

    Nozaki A, Atsukawa M, Kondo C, Toyoda H, Chuma M, Nakamuta M, Uojima 6, Takaguchi K, Ikeda H, Watanabe T, Ogawa S, Itokawa N, Arai T, Hiraoka A, Asano T, Fujioka S, Ikegami T, Shima T, Ogawa C, Akahane T, Shimada N, Fukunishi S, Abe H, Tsubota A, Genda T, Okubo H, Mikami S, Morishita A, Moriya A, Tani J, Tachi Y, Hotta N, Ishikawa T, Okanoue T, Tanaka Y, Kumada T, Iwakiri K, Maeda S; KTK49 Liver Study Group.
    7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

    Antiviral Res 176/P.104744-/2020

    Hayashi S, Higashi-Kuwata N, Das D, Tomaya K, Yamada K, Murakami S, Venzon DJ, Hattori SI, Isogawa M, Sarafianos SG, Mitsuya H, Tanaka Y
    JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study.

    J Gastroenterol 55/P.640-652/2020

    Takehara T, Chayama K, Kurosaki M, Yatsuhashi H, Tanaka Y, Hiramatsu N, Sakamoto N, Asahina Y, Nozaki A, Nakano T, Hagiwara Y, Shimizu H, Yoshida H, Huang Y, Biermer M, Vijgen L, Hayashi N.
    Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

    Hepatol Commun 4/P.255-267/2020

    Kiso A, Toba Y, Tsutsumi S, Deguchi S, Igai K, Koshino S, Tanaka Y, Takayama K, Mizuguchi H.
    Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.

    J Gastroenterol Hepatol 35/P.1420-1425/2020

    Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Iwakiri K, Kumada T, Tanaka Y, Okanoue T.
    MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion.

    Cancer Sci 111/P.869-880/2020

    Yasukawa K, Liew LC, Hagiwara K, Hironaka-Mitsuhashi A, Qin XY, Furutani Y, Tanaka Y, Nakagama H, Kojima S, Kato T, Ochiya T, Gailhouste L.
    Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.

    Carcinogenesis 41/P.1145-1157/2020

    Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S.
    HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication.

    Clin Infect Dis 71/P.2840-2848/2020

    Ogawa E, Toyoda H, Iio E, Jun DW, Huang CF, Enomoto M, Hsu YC, Haga H, Iwane S, Wong G, Lee DH, Tada T, Liu CH, Chuang WL, Hayashi J, Cheung R, Yasuda S, Tseng CH, Takahashi H, Tran S, Yeo YH, Henry L, Barnett SD, Nomura H, Nakamuta M, Dai CY, Huang JF, Yang HI, Lee MH, Jung Jun M, Kao JH, Eguchi Y, Ueno Y, Tamori A, Furusyo N, Yu ML, Tanaka Y, Nguyen MH; REAL-C Investigators, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL. Investigators, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL.
    Tenofovir versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B

    Am J Gastroenterol 115/P.271-280/2020

    Hsu YC, Wong GL, Chen CH, Peng CY, Yeh ML, Cheung KS, Toyoda H, Huang CF, Trinh H, Xie Q, Enomoto M, Liu L, Yasuda S, Tanaka Y, Kozuka R, Tsai PC, Huang YT, Wong C, Huang R, Jang TY, Hoang J, Yang HI, Li J, Lee DH, Takahashi H, Zhang JQ, Ogawa E, Zhao C, Liu C, Furusyo N, Eguchi Y, Wong C, Wu C, Kumada T, Yuen MF, Yu ML, Nguyen MH.
    Cure with Interferon Free DAA is Associated with Increased Survival in Patients with HCV related HCC from both East and West.

    Hepatology 71/P.1910-1922/2020

    Dang H, Yeo YH, Yasuda S, Huang CF, Iio E, Landis C, Jun DW, Enomoto M, Ogawa E, Tsai PC, Le A, Liu M, Maeda M, Nguyen B, Ramrakhiani N, Henry L, Cheung R, Tamori A, Kumada T, Tanaka Y, Yu ML Toyoda H, Nguyen MH.
    Real-world experience of 12-week DAA regimen of glecaprevir and pibrentasvir in patients with chronic HCV infection.

    J Gastroenterol Hepatol 35/P.855-861/2020

    Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Tanaka Y, Iwakiri K, Kumada T
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ⓒ Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University