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Research & achievements研究・業績aaa

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2021年度

  • 2021年度

    Long-term outcomes after endoscopic resection for late elderly patients with early
    gastric cancer

    Gastrointest Endosc  S0016-5107(21)01942-8./P.-/2021

    Waki K, Shichijo S, Uedo N, Takeuchi Y, Maekawa A, Kanesaka T, Takeuchi Y, Higashino K, Ishihara R, Tanaka Y, Michida T.
    Treatment strategies for reducing early and late recurrence of colonic diverticular bleeding based on stigmata of recent hemorrhage: a large multicenter study

    Gastrointest Endosc S0016-5107(21)01937-4/P.-/2021

    Gobinet MS, Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Uemura N, Itawa E, Sugimoto M, Fukuzawa M, Kawai T, Kaise M, Itoi T.
    Development of hepatocellular carcinoma from various phases of chronic hepatitis B virus infection

    PLoS One 16/P.e0261878-/2021

    Suzuki T, Matsuura K, Nagura Y, Iio E, Ogawa S, Fujiwara K, Nojiri S, Kataoka H, Tanaka Y.
    Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study

    BMC Gastroenterol 21/P.489-/2021

    Suzuki F, Suzuki Y, Karino Y, Tanaka Y, Kurosaki M, Yatsuhashi H, Atarashi T, Atsukawa M, Watanabe T, Enomoto M, Kudo M, Maeda N, Kohno H, Joko K, Michitaka K, Miki K, Takahashi K, Ide T, Fujiyama S,Kohno T, Itoh H, Tsukamoto S, Suzuki Y, Kawano Y,Sugiura W and Kumada H
    Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma

    Hepatol Commun 2021 Nov 27. doi: 10.1002/hep4.1872./P.-/2021

    Narahara S, Watanabe T, Nagaoka K, Fujimoto N, Furuta Y, Tanaka K, Tokunaga T, Kawasaki T, Yoshimaru Y, Setoyama H, Oniki K, Saruwatari J, Tateyama M, Naoe H, Tanaka M, Tanaka Y, Sasaki Y
    Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study

    World Journal of Gastrointestinal Endoscopy 13/P.491-501/2021

    Miyamoto H, Naoe H, Morinaga J, Sakisaka K, Tayama S, Matsuno K, Gushima R, Tateyama M, Shono T, Imuta M, Miyamaru S, Murakami D, Orita Y and Tanaka Y.
    Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B

    microorganisms 9/P.2083-/2021

    Watanabe T, Inoue T, Tanaka Y.
    Blood‐Based Biomarkers in Hepatitis B Virus‐Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins

    Int. J. Mol. Sci 22/P.11051-/2021

    Hayashi S, Nagaoka K, Tanaka Y.
    All-atom molecular dynamics study of hepatitis B virus containing pregenome RNA in solution

    J Chem Phys 155/P.145101-/2021

    Fujimoto K, Yamaguchi Y, Urano R, Shinoda W, Ishikawa T, Omagari K, Tanaka Y, Nakagawa A and Okazaki S
    Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

    Sci Rep 11/P.20373-/2021

    Ishii N, Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Omata F, Shiratori Y, Imamura N, Yano T, Kaise M.
    Identifying Bleeding Etiologies by Endoscopy Affected Outcomes in 10,342 Cases With Hematochezia: CODE BLUE-J Study

    Am J Gastroenterol 116/P.2222-2234/2021

    Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Fukuzawa M, Itoi T, Uemura N, Kawai T, Kaise M.
    A Genome-Wide Association Study Identifying SVEP1 Variant as a Predictor of Response to Tolvaptan for Cirrhotic Ascites.

    Liver Int 41/P.2944-2953/2021

    Kawaratani H, Sawai H, Onishi M, Kogiso T, Shimada N, Uojima H, Nakajima T, Matsumoto N, Ikejima K, Ishikawa T, Terai S, Motoyama H, Komori A, Hirashima N, Saito S, Eguchi Y, Nojima M, Kawai Y, Tateyama M, Yoshiji H, Tanaka Y.
    N-glycan structures of Wisteria floribunda agglutinin-positive Mac2 binding protein in the serum of patients with liver fibrosis.

    Glycobiology 31/P.1268-1278/2021

    Noro E, Matsuda A, Kyoutou T, Sato T, Tomioka A, Nagai M, Sogabe M, Tsuruno C, Takahama Y, Kuno A, Tanaka Y, Kaji H, Narimatsu H.
    Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

    Clin Gastroenterol Hepatol S1542-3565(21)00601-7./P.-/2021

    Park J, Le AK, Tseng TC, Yeh ML, Jun DW, Trinh H, Wong G LH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung KS, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH.
    Application of Fluorescent-Based Technology Detecting Protein-Protein Interactions to Monitor the Binding of Hepatitis B Virus X protein to DNA-damage-binding protein 1.

    BPPB 18/P.67-77/2021

    Omagari K, Asamitsu K and Tanaka Y.
    Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA.

    Sci Rep 11/P.8672-/2021

    Yukawa H, Yamazaki S, Aoki K, Muto K, Kihara N, Sato K, Onoshima D, Ochiya T, Tanaka Y, Baba Y.
    Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation.

    J Hepatol 75/P.302-310/2021

    Inoue T, Kusumoto S, Iio E, Ogawa S, Suzuki T, Yagi S, Kaneko A, Matsuura K, Aoyagi K, Tanaka Y.
    Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.

    Nat Metab 3/P.196-210/2021

    Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T,Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y, Kawamura. K Y, Tonami K, Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N and Tsujita K.
    Liver fibrosis improvement assessed by magnetic resonance elastography and Mac-2-binding protein glycosylation isomer in patients with hepatitis C virus infection receiving direct-acting antivirals.

    Hepatol Res 51/P.528-537/2021

    Chuaypen N, Chittmittrapap S, Avihingsanon A, Siripongsakun S, Wongpiyabovorn J, Tanpowpong N, Tanaka Y, Tangkijvanich P.
    Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection.

    Infect Dis.  24/P.1410-1421/2021

    Chuaypen N, Jinato T, Avihingsanon A, Chirapongsathorn S, Cheevadhanarak S, Nookaew I, Tanaka Y, Tangkijvanich P.J
    Prophylactic antiviral therapy for hepatitis B virus surface antigen-positive patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy

    Cancer Sci 112/P.1943-1954/2021

    Yamauchi N, Maruyama D, Choi I, Atsuta Y, Sakai R, Miyashita K, Moriuchi Y, Tsujimura H, Kubota N, Yamamoto G, Igarashi T, Izutsu K, Yoshida S, Kojima K, Uchida T, Inoue Y, Tsukamoto N, Ohtsuka E, Suzuki S, Inaguma Y, Ichikawa S, Gomyo H, Ushijima Y, Nosaka K, Kurata M, Yasuhito Tanaka Y, Ueda R, Mizokami M, Kusumoto S.
    Analysis of Hepatitis B virus genotype D in Greenland suggests presence of novel subgenotype .

    Front Microbiol 11/P.602296-/2021

    Bernardi Schneider A-de, Hostager R, Krarup H, Børresen M, Tanaka Y, Morriseau T, Osiowy C and Wertheim J-O.
    Usefulness of an artificial intelligence system for the detection of esophageal squamous cell carcinoma evaluated with videos simulating overlooking situation

    Dig Endosc 33/P.1101-1109/2021

    Waki K, Ishihara R, Kato Y, Shoji A, Inoue T, Matsueda K, Miyake M, Shimamoto Y, Fukuda H, Matsuura N, Ono Y, Yao K, Hashimoto S, Terai S, Ohmori M, Tanaka K, Kato M, Shono T, Miyamoto H, Tanaka Y, Tada T
    Risk stratification for advanced colorectal neoplasia based on the findings of the index and first surveillance colonoscopies.

    PLoS One 16/P.e0245211-/2021

    Honda M, Naoe H, Honda M, Naoe H, Gushima R, Miyamoto H, Tateyama M, Oda Y, Murakami Y, Tanaka Y.
    Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients infected patients.

    Sci Rep 11/P.960-/2021

    Imahashi M, Ode H, Kobayashi A, Nemoto M, Matsuda M, Hashiba C, Hamano A, Nakata Y, Mori M, Seko K,Nakahata M, Kogure A, Tanaka Y, Sugiura W, Yokomaku Y,Iwatani Y.
    Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients.

    Hepatol Int 15/P.71-81/2021

    Liu M, Tseng TC, Jun DW, Yeh ML, Trinh H, Wong GLH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung M, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng CH, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH.
    Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

    J Hepatol 74/P.1075-1086/2021

    Higashi-Kuwata N, Hayashi S, Kumamoto H, Ogata-Aoki H, Das D , Venzon D, Hattori S, Bulut H, Hashimoto M, Otagiri M, Takamune N, Kishimoto N, Davis A-D, Misumi S, Kakuni, M Tanaka Y, Mitsuya H.
    Ten-Eleven Translocation 1 Promotes Malignant Progression of Cholangiocarcinoma With Wild-Type Isocitrate Dehydrogenase 1

    Hepatology 73/P.1747-1763/2021

    Bai X, Zhang H, Zhou Y, Nagaoka K, Ji C, Cao K, Mulla J, Cheng Z, Mueller W, Bay A, Hildebrand G, Lu S, Wallace J, Wands JR, Sun B*, Huang CK*.
    Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants.

    Clin Gastroenterol Hepatol 19/P.46-60.e8/2021

    Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey , Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen H, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJ, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y.
    "Improved visibility of early gastric cancer using a combination of chromoendoscopy
    and Texture and Color Enhancement Imaging"

    "Gastrointest Endosc  S0016-5107(21)01930-1./P.-/2021"

    Waki K, Kanesaka T, Michida T, Ishihara R, Tanaka Y.
    A female patient with GSD IXc developing multiple and recurrent hepatocellular carcinoma: a case report and literature review.

    Hum Genome Var 8/P.45-/2021

    Kido J, Mitsubuchi H, Watanabe T, Sugawara K, Sasai H, Fukao T, Nakamura K.
    Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy.

    Anticancer Res 41/P.5855-5861/2021

    Adachi Y, Yamamura K, Yumoto S, Higashi T, Ishiodori H, Honda S, Hara Y, Matsumura K, Oda E, Akahoshi S, Yuki H, Miyamoto H, Doi K, Beppu T
    Exosomal circCMTM3 promotes the pathogenesis of hepatocellular carcinoma via angiogenesis.

    Hepatol Res 51/P.1100-1101/2021

    Watanabe T, Tanaka M.
    Mac-2 binding protein and its glycan isomer: Where does it come from? Where is it going?

    Hepatol Res 51/P.1026-1028/2021

    Nagaoka K ,Tanaka M, Tanaka Y.
    Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor.

    Anticancer Res 41/P.5249-5254/2021

    Oda E, Yamamura K, Hara Y, Matsumura K, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Kinoshita K, Matsumura F, Ohnishi K, Komohara Y, Beppu T
    Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage.

    Anticancer Res 41/P.2727-2732/2021

    Yamamura K, Beppu T, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Miyamura S, Onishi K, Komohara Y, Akahoshi S
    Huge hepatocellular carcinoma with extrahepatic collateral arteries successfully treated by multidisciplinary treatment including laparoscopic devascularization: a case report.

    Clin J Gastroenterol 14/P.251-257/2021

    Yamamura K, Beppu T, Sato N, Oda E, Kinoshita K, Yuki H, Motohara T, Miyamoto H, Oda T, Akahoshi S
    Case of hepatitis B virus reactivation after ibrutinib therapy in which the patient remained negative for hepatitis B surface antigens throughout the clinical course

    Hepatol Res 51/P.239-244/2021

    Tsuruya K, Anzai K, Shioyama S, Ito A, Arase Y, Hirose S , Tanaka Y, Suzuki H, Kagawa T.
    Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy: A randomized controlled trial.

    Clin Gastroenterol Hepatol S1542-3565(21)00872-7./P.-/2021

    Kato S, Kuwatani M, Onodera M, Kudo T, Sano I, Katanuma A, Uebayashi M, Eto K, Fukasawa M, Hashigo S, Iwashita T, Yoshida M, Taya Y, Kawakami H, Kato H, Nakai Y, Kobashigawa K, Kawahata S, Shinoura S, Ito K, Kubo K, Yamato H, Hara K, Maetani I, Mukai T, Shibukawa G, Itoi T.
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ⓒ Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University