Successful treatment of occult pancreatic melanoma using BRAF/MEK inhibitors.

J Dermatol　47,P.e126-e147　/　2020

Mizukami Y, Kanemaru H, Nakamura K, Hashigo S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Honda Y, Ihn H.

Successful treatment of adult-onset type II citrullinemia with a low-carbohydrate diet and L-arginine after DNA analysis produced a definitive diagnosis

Clin J Gastroenterol　13,P.823-833　/　2020

Unita S, Hirashima N, Shimada M, Tsunekawa T, Tanaka D, Kondo T, Urata N, Kondo H, Saito M, Iwase H, Ito S, Togawa T, Saitoh S , Tanaka Y.

Cytomegalovirus enterocolitis in a patient with refractory immune-related colitis.

Case Rep Gastroenterol　14,P.103-109　/　2020

Furuta Y, Miyamoto H, Naoe H, Shimoda M, Hinokuma Y, Miyamura T, Miyashita A, Fukushima S, Tanaka M, Sasaki Y

Hepatitis B virus reactivation in a myeloma patient with resolved infection who received daratumumab-containing salvage chemotherapy

J Clin Exp Hematop　60,P.51-54　/　2020

Kikuchi T, Kusumoto S, Tanaka Y, Oshima Y, Fujinami H, Suzuki T, Totani H, Kinoshita S, Asao Y, Narita T, Ito A, Ri M, Komatsu H, Iida S.

Multiple Gastric Polyps Improved After Treatment for Ulcerative Colitis.

Inflamm Bowel Dis　26,P.e144-e145　/　2020

Tsuruta Y, Furuta Y, Naoe H, Tanaka M

Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer

Intern Med　59,P.2499-2504　/　2020

Higashi T, Miyamoto H, Yoshida R, Furuta Y, Nagaoka K, Naoe H, Naito H, Nakayama H, Tanaka M

Complete Removal of Adrenal Metastasis in Hepatocellular Carcinoma Using Indocyanine Green Fluorescent Imaging.

Anticancer Res　40,P.5823-5828　/　2020

Yamamura K, Beppu T, Sato N, Kinoshita K, Oda E, Yuki H, Motohara T, Miyamoto H, Komohara Y, Akahoshi S

Hepatocellular Carcinoma With Extensive Cancer-associated Thrombosis Successfully Treated With Liver Resection and Direct Oral Anticoagulant: A Case Report.

Anticancer Res　40,P.6465-6471　/　2020

Yamamura K, Beppu T, Kinoshita K, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Kawaguchi H, Komohara Y, Akahoshi S

Cholangiolocarcinoma With Multiple Recurrences Successfully Treated With Repeated Liver Resection and Radiofrequency Ablation.

Anticancer Res　40,P.7147-7153　/　2020

Sato N, Yamamura K, Oda E, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Yoshii D, Komohara Y, Beppu T

HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort

Hepatol Int　14,P.1023-1033　/　2020

Tanaka Y, Ogawa E, Huang C-F, Toyoda H, Won Jun D, Tseng C-H, Hsu Y-C, Enomoto M, Takahashi H, Furusyo N, Yeh M-L, Iio E, Yasuda S, Pui-Mei Lam C, Hyun Lee D, Haga H, L Yoon E, Bong Ahn S, Wong G, Nakamuta M, Nomura H, Tsai P-C, Han Jung J, Seon Song D, Dang H, Maeda M, Henry L, Cheung R, Yuen M-F, Ueno Y, Eguchi Y, Tamori A, Yu M-L, Hayashi J, Nguyen M H, REAL-C Investigators

Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study.

BMC Gastroenterol　20,P.371　/　2020

Tateyama M, Naoe H, Tanaka M, Tanaka K, Narahara S, Tokunaga T, Kawasaki T, Yoshimaru Y, Nagaoka K, Watanabe T, Setoyama H, Sasaki Y, Tanaka Y.

Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.

Cell Rep　33,P.108265　/　2020

Inazumi T, Yamada K, Shirata N, Sato H, Taketomi Y, Morita K, Hohjoh H, Tsuchiya S, Oniki K, Watanabe T, Sasaki Y, Oike Y, Ogata Y, Saruwatari J, Murakami M, Sugimoto Y

Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

Virus Res　290,P.198191　/　2020

HoqueKayesha M-E, Amakod Y, Hashema M A, Murakami S, Ogawa S, Yamamoto N, Hifumi T, Miyoshi N, Sugiyama M ,Tanaka Y, Mizokami M, Kohara M, Tsukiyama-Kohara K.

Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture

Int. J. Mol. Sci　21,P.7251　/　2020

Hamada-Tsutsumi S, Onishi M, Matsuura K, Isogawa M, Kawashima K, Sato Y, Tanaka Y.

Pancreatic neuroendocrine carcinoma G3 may be heterogeneous and could be classified into two distinct groups.

Pancreatology　20,P.1421-1427　/　2020

Tanaka H, Hijioka S, Hosoda W, Ueno M, Kobayashi N, Ikeda M, Ito T, Kodama Y, Morizane C, Notohara K, Taguchi H, Kitano M, Komoto I, Tsuji A, Hashigo S, Kanno A, Miyabe K, Takagi T, Ishii H, Kojima Y, Yoshitomi H, Yanagimoto H, Furuse J, Mizuno N.

Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus

Hepatol Res　50,P.1128-1140　/　2020

Ito K, Angata K, Kuno A, Okumura A, Sakamoto K, Inoue R, Morita N, Watashi K, Wakita T, Tanaka Y, Sugiyama M, Mizokami M, Yoneda M, Narimatsu H

Hepatitis B surface antigen, core-related antigen and HBV RNA: Predicting clinical relapse after NA therapy discontinuation.

Liver Int　40,P.2961-2971　/　2020

Kaewdech A, Tangkijvanich P, Sripongpun P, Witeerungrot T, Jandee S, Tanaka Y, Piratvisuth T.

Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis

Dig Dis Sci.　66,P.1080-1089　/　2020

Nagaoka K (equal 1st), Ogawa K, Ji C, Cao KY, Bai X, Mulla J, Cheng Z, Wands JR, Huang CK*.

Baseline Mac-2 Binding Protein Glycosylation Isomer Level Stratifies Risks of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Oral Antiviral Therapy

Liver Cancer　9,P.207-220　/　2020

Tseng T.-C, Peng C.-Y, Hsu Y.-C, Su T.-H, Wang C.-C, Liu C.-J, Yang H.-C., Yang W.-T, Lin C.-H, Yu M.-L, Lai H.-C , Tanaka Y, Nguyen M.H , Liu C.-H , Chen P.-J , Chen D.-S , Kao J.-H.

The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism

Liver Research　9,P.94-100　/　2020

Nagaoka K , Mulla J, Cao K, Cheng Z, Liu D, William Muellera Bay, A, Hildebrand, G, Lu, S, Huang, CK*.

"Ultra-high sensitivity HBsAg assay can diagnose HBV reactivation following rituximab-based therapy in patients with lymphoma"

J Hepatol　73,P.285-293　/　2020

Kusumoto S, Tanaka Y (equal 1st), Suzuki R, Watanabe T, Nakata M, Sakai R, Fukushima N, Fukushima T, Moriuchi Y, Itoh K, Nosaka K, Choi I, Sawa M, Okamoto R, Tsujimura H, Uchida T, Suzuki S, Okamoto M, Takahashi T, Sugiura I, Onishi 0, Kohri M, Yoshida S, Kojima M, Takahashi H, Tomita A, Atsuta Y, Maruyama D, Tanaka E, Suzuki T, Kinoshita T, Ogura M, Ueda R, Mizokami M.

Fluorescence-based biochemical analysis of human hepatitis B virus reverse transcriptase activity

Anal Biochem　597,P.113642　/　2020

ToyodaT, Wang Y, Wen Y, Tanaka Y.

Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions.

Sci Rep　10,P.4313　/　2020

Oniki K, Kawakami T, Nakashima A, Miyata K, Watanabe T, Fujikawa H, Nakashima R, Nasu A, Eto Y, Takahashi N, Nohara H, Ann Suico M, Kotani S, Obata Y, Sakamoto Y, Seguchi Y, Saruwatari J, Imafuku T, Watanabe H, Maruyama T, Kai H,Shuto T.

Prometastatic Secretome Trafficking via Exosomes Initiates Pancreatic Cancer Pulmonary Metastasis.

Cancer Lett　481,P.63-75　/　2020

Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B*, Wands J*, Dong X*

The effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients with refractory factors in the real world:

Hepatol Int　14,P.225-238　/　2020

Nozaki A, Atsukawa M, Kondo C, Toyoda H, Chuma M, Nakamuta M, Uojima 6, Takaguchi K, Ikeda H, Watanabe T, Ogawa S, Itokawa N, Arai T, Hiraoka A, Asano T, Fujioka S, Ikegami T, Shima T, Ogawa C, Akahane T, Shimada N, Fukunishi S, Abe H, Tsubota A, Genda T, Okubo H, Mikami S, Morishita A, Moriya A, Tani J, Tachi Y, Hotta N, Ishikawa T, Okanoue T, Tanaka Y, Kumada T, Iwakiri K, Maeda S; KTK49 Liver Study Group.

A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.

Diabetes Metab Syndr Obes　13,P.333-341　/　2020

Muto N, Oniki K, Kudo M, Obata Y, Sakamoto Y, Tokumaru N, Izuka T, Watanabe T, Otake K, Ogata Y, Saruwatari J

7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

Antiviral Res　176,P.104744　/　2020

Hayashi S, Higashi-Kuwata N, Das D, Tomaya K, Yamada K, Murakami S, Venzon DJ, Hattori SI, Isogawa M, Sarafianos SG, Mitsuya H, Tanaka Y

JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study.

J Gastroenterol　55,P.640-652　/　2020

Takehara T, Chayama K, Kurosaki M, Yatsuhashi H, Tanaka Y, Hiramatsu N, Sakamoto N, Asahina Y, Nozaki A, Nakano T, Hagiwara Y, Shimizu H, Yoshida H, Huang Y, Biermer M, Vijgen L, Hayashi N.

Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

Hepatol Commun　4,P.255-267　/　2020

Kiso A, Toba Y, Tsutsumi S, Deguchi S, Igai K, Koshino S, Tanaka Y, Takayama K, Mizuguchi H.

Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.

J Gastroenterol Hepatol　35,P.1420-1425　/　2020

Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Iwakiri K, Kumada T, Tanaka Y, Okanoue T.

MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion.

Cancer Sci　111,P.869-880　/　2020

Yasukawa K, Liew LC, Hagiwara K, Hironaka-Mitsuhashi A, Qin XY, Furutani Y, Tanaka Y, Nakagama H, Kojima S, Kato T, Ochiya T, Gailhouste L.

Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.

Carcinogenesis　41,P.1145-1157　/　2020

Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S.

HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication.

Clin Infect Dis　71,P.2840-2848　/　2020

Ogawa E, Toyoda H, Iio E, Jun DW, Huang CF, Enomoto M, Hsu YC, Haga H, Iwane S, Wong G, Lee DH, Tada T, Liu CH, Chuang WL, Hayashi J, Cheung R, Yasuda S, Tseng CH, Takahashi H, Tran S, Yeo YH, Henry L, Barnett SD, Nomura H, Nakamuta M, Dai CY, Huang JF, Yang HI, Lee MH, Jung Jun M, Kao JH, Eguchi Y, Ueno Y, Tamori A, Furusyo N, Yu ML, Tanaka Y, Nguyen MH; REAL-C Investigators, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL. Investigators, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL.

Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study).

Gastrointest Endosc　91,P.373-381.e2.　/　2020

Kurita A, Yasukawa S, Zen Y, Yoshimura K, Ogura T, Ozawa E, Okabe Y, Asada M, Nebiki H, Shigekawa M, Ikeura T, Eguchi T, Maruyama H, Ueki T, Itonaga M, Hashimoto S, Shiomi H, Minami R, Hoki N, Takenaka M, Itokawa Y, Uza N, Hashigo S, Yasuda H, Takada R, Kamada H, Kawamoto H, Kawakami H, Moriyama I, Fujita K, Matsumoto H, Hanada K, Takemura T, Yazumi S.

Tenofovir versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B

Am J Gastroenterol　115,P.271-280　/　2020

Hsu YC, Wong GL, Chen CH, Peng CY, Yeh ML, Cheung KS, Toyoda H, Huang CF, Trinh H, Xie Q, Enomoto M, Liu L, Yasuda S, Tanaka Y, Kozuka R, Tsai PC, Huang YT, Wong C, Huang R, Jang TY, Hoang J, Yang HI, Li J, Lee DH, Takahashi H, Zhang JQ, Ogawa E, Zhao C, Liu C, Furusyo N, Eguchi Y, Wong C, Wu C, Kumada T, Yuen MF, Yu ML, Nguyen MH.

Cure with Interferon Free DAA is Associated with Increased Survival in Patients with HCV related HCC from both East and West.

Hepatology　71,P.1910-1922　/　2020

Dang H, Yeo YH, Yasuda S, Huang CF, Iio E, Landis C, Jun DW, Enomoto M, Ogawa E, Tsai PC, Le A, Liu M, Maeda M, Nguyen B, Ramrakhiani N, Henry L, Cheung R, Tamori A, Kumada T, Tanaka Y, Yu ML Toyoda H, Nguyen MH.

Real-world experience of 12-week DAA regimen of glecaprevir and pibrentasvir in patients with chronic HCV infection.

J Gastroenterol Hepatol　35,P.855-861　/　2020

Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Tanaka Y, Iwakiri K, Kumada T

Risk stratification of advanced colorectal neoplasia after baseline colonoscopy: Cohort study of 17 Japanese community practices.

Dig Endosc　32,P.106-113　/　2020

Shono T, Oyama S, Oda Y, Yokomine K, Murakami Y, Miyamoto H, Tanaka M, Naoe H, Sasaki Y ,Kumamoto Colon Cancer, Study Group

Endoscopic features of esophageal adenocarcinoma derived from short-segment versus long-segment Barrett’s esophagus

J Gastroenterol Hepatol　35,P.211-217　/　2020

Yamasaki A, Shimizu T, Kawachi H, Yamamoto N, Yoshimizu S, Horiuchi Y, Ishiyama A, Yoshio T, Hirasawa T, Tsuchida T, Sasaki Y, Fujisaki J