Case of hepatitis B virus reactivation after ibrutinib therapy in which the patient remained negative for hepatitis B surface antigens throughout the clinical course

Hepatol Res　51,P.239-244　/　2021

Tsuruya K, Anzai K, Shioyama S, Ito A, Arase Y, Hirose S , Tanaka Y, Suzuki H, Kagawa T.

Huge hepatocellular carcinoma with extrahepatic collateral arteries successfully treated by multidisciplinary treatment including laparoscopic devascularization: a case report.

Clin J Gastroenterol　14,P.251-257　/　2021

Yamamura K, Beppu T, Sato N, Oda E, Kinoshita K, Yuki H, Motohara T, Miyamoto H, Oda T, Akahoshi S

Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage.

Anticancer Res　41,P.2727-2732　/　2021

Yamamura K, Beppu T, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Miyamura S, Onishi K, Komohara Y, Akahoshi S

Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor.

Anticancer Res　41,P.5249-5254　/　2021

Oda E, Yamamura K, Hara Y, Matsumura K, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Kinoshita K, Matsumura F, Ohnishi K, Komohara Y, Beppu T

Mac-2 binding protein and its glycan isomer: Where does it come from? Where is it going?

Hepatol Res　51,P.1026-1028　/　2021

Nagaoka K ,Tanaka M, Tanaka Y.

Exosomal circCMTM3 promotes the pathogenesis of hepatocellular carcinoma via angiogenesis.

Hepatol Res　51,P.1100-1101　/　2021

Watanabe T, Tanaka M.

Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy.

Anticancer Res　41,P.5855-5861　/　2021

Adachi Y, Yamamura K, Yumoto S, Higashi T, Ishiodori H, Honda S, Hara Y, Matsumura K, Oda E, Akahoshi S, Yuki H, Miyamoto H, Doi K, Beppu T

A female patient with GSD IXc developing multiple and recurrent hepatocellular carcinoma: a case report and literature review.

Hum Genome Var　8,P.45　/　2021

Kido J, Mitsubuchi H, Watanabe T, Sugawara K, Sasai H, Fukao T, Nakamura K.

"Improved visibility of early gastric cancer using a combination of chromoendoscopy and Texture and Color Enhancement Imaging"

Gastrointest Endosc　S0016-5107(21)01930-1.　/　2021

Waki K, Kanesaka T, Michida T, Ishihara R, Tanaka Y.

Development of hepatocellular carcinoma from various phases of chronic hepatitis B virus infection.

PLoS One　16,P.e0261878　/　2021

Suzuki T, Matsuura K, Nagura Y, Iio E, Ogawa S, Fujiwara K, Nojiri S, Kataoka H, Tanaka Y.

Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR.

Cancers (Basel).　13,P.3455　/　2021

Yeh ML, Liang PC, Tsai PC, Wang SC, Leong J, Ogawa E, Jun DW, Tseng CH, Landis C, Tanaka Y, Huang CF, Hayashi J, Hsu YC, Huang JF, Dai CY, Chuang WL, Nguyen MH, Yu ML.

The risk of cirrhosis and its complications based on PNPLA3 rs738409 G allele frequency.

Dig Dis　/　2021

Shao X, Uojima H, Arai T, Ogawa Y, Setsu T, Atsukawa M, Furuichi Y, Arase Y, Horio K, Hidaka H, Nakazawa T, Kako M, Kagawa T, Iwakiri K, Nakajima A, Terai S, Tanaka Y, Koizumi W.

A novel noninvasive formula for predicting cirrhosis in patients with chronic hepatitis C.

PLoS One. 　16,P.e0257166　/　2021

Atsukawa M, Tsubota A, Kondo C, Uchida-Kobayashi S, Takaguchi K, Tsutsui A, Nozaki A, Chuma M, Hidaka I, Ishikawa T, Iwasa M, Tamai Y, Tobari M, Matsuura K, Nagura Y, Abe H, Kato K, Suzuki K, Okubo T, Arai T, Itokawa N, Toyoda H, Enomoto M, Tamori A, Tanaka Y, Kawada N, Takei Y, Iwakiri K.

Long-term outcomes after endoscopic resection for late elderly patients with early gastric cancer

Gastrointest Endosc　S0016-5107(21)01942-8.　/　2021

Waki K, Shichijo S, Uedo N, Takeuchi Y, Maekawa A, Kanesaka T, Takeuchi Y, Higashino K, Ishihara R, Tanaka Y, Michida T.

Treatment strategies for reducing early and late recurrence of colonic diverticular bleeding based on stigmata of recent hemorrhage: a large multicenter study

Gastrointest Endosc　S0016-5107(21)01937-4　/　2021

Gobinet MS, Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Uemura N, Itawa E, Sugimoto M, Fukuzawa M, Kawai T, Kaise M, Itoi T.

Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study

BMC Gastroenterol　21,P.489　/　2021

Suzuki F, Suzuki Y, Karino Y, Tanaka Y, Kurosaki M, Yatsuhashi H, Atarashi T, Atsukawa M, Watanabe T, Enomoto M, Kudo M, Maeda N, Kohno H, Joko K, Michitaka K, Miki K, Takahashi K, Ide T, Fujiyama S,Kohno T, Itoh H, Tsukamoto S, Suzuki Y, Kawano Y,Sugiura W and Kumada H

Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma

Hepatol Commun　2021 Nov 27. doi: 10.1002/hep4.1872.　/　2021

Narahara S, Watanabe T, Nagaoka K, Fujimoto N, Furuta Y, Tanaka K, Tokunaga T, Kawasaki T, Yoshimaru Y, Setoyama H, Oniki K, Saruwatari J, Tateyama M, Naoe H, Tanaka M, Tanaka Y, Sasaki Y

Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study

World J Gastrointest Endosc　13,P.491-501　/　2021

Miyamoto H, Naoe H, Morinaga J, Sakisaka K, Tayama S, Matsuno K, Gushima R, Tateyama M, Shono T, Imuta M, Miyamaru S, Murakami D, Orita Y and Tanaka Y.

Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B

microorganisms　9,P.2083　/　2021

Watanabe T, Inoue T, Tanaka　Y.

Blood‐Based Biomarkers in Hepatitis B Virus‐Related　Hepatocellular Carcinoma, Including the Viral Genome and　Glycosylated Proteins

Int. J. Mol. Sci　22,P.11051　/　2021

Hayashi S, Nagaoka K (equal 1st), Tanaka Y.

All-atom molecular dynamics study of hepatitis B virus containing pregenome RNA in solution

J Chem Phys　155,P.145101　/　2021

Fujimoto K, Yamaguchi Y, Urano R, Shinoda W, Ishikawa T, Omagari K, Tanaka Y, Nakagawa A and Okazaki S

Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

Sci Rep　11,P.20373　/　2021

Ishii N, Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Omata F, Shiratori Y, Imamura N, Yano T, Kaise M.

Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy: A randomized controlled trial.

Clin Gastroenterol Hepatol　S1542-3565(21)00872-7.　/　2021

Kato S, Kuwatani M, Onodera M, Kudo T, Sano I, Katanuma A, Uebayashi M, Eto K, Fukasawa M, Hashigo S, Iwashita T, Yoshida M, Taya Y, Kawakami H, Kato H, Nakai Y, Kobashigawa K, Kawahata S, Shinoura S, Ito K, Kubo K, Yamato H, Hara K, Maetani I, Mukai T, Shibukawa G, Itoi T.

Identifying Bleeding Etiologies by Endoscopy Affected Outcomes in 10,342 Cases With Hematochezia: CODE BLUE-J Study

Am J Gastroenterol　116,P.2222-2234　/　2021

Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Fukuzawa M, Itoi T, Uemura N, Kawai T, Kaise M.

A Genome-Wide Association Study Identifying SVEP1 Variant as a Predictor of Response to Tolvaptan for Cirrhotic Ascites.

Liver Int　41,P.2944-2953　/　2021

Kawaratani H, Sawai H, Onishi M, Kogiso T, Shimada N, Uojima H, Nakajima T, Matsumoto N, Ikejima K, Ishikawa T, Terai S, Motoyama H, Komori A, Hirashima N, Saito S, Eguchi Y, Nojima M, Kawai Y, Tateyama M, Yoshiji H, Tanaka Y.

N-glycan structures of Wisteria floribunda agglutinin-positive Mac2 binding protein in the serum of patients with liver fibrosis.

Glycobiology　31,P.1268-1278　/　2021

Noro E, Matsuda A, Kyoutou T, Sato T, Tomioka A, Nagai M, Sogabe M, Tsuruno C, Takahama Y, Kuno A, Tanaka Y, Kaji H, Narimatsu H.

Application of Fluorescent-Based Technology Detecting Protein-Protein Interactions to Monitor the Binding of Hepatitis B Virus X protein to DNA-damage-binding protein 1.

BPPB　18,P.67-77　/　2021

Omagari K, Asamitsu K and Tanaka Y.

Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA.

Sci Rep　11,P.8672　/　2021

Yukawa H, Yamazaki S, Aoki K, Muto K, Kihara N, Sato K, Onoshima D, Ochiya T, Tanaka Y, Baba Y.

Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation.

J Hepatol　75,P.302-310　/　2021

Inoue T, Kusumoto S, Iio E, Ogawa S, Suzuki T, Yagi S, Kaneko A, Matsuura K, Aoyagi K, Tanaka Y.

Modifed albumin–bilirubin grade to predict eligibility for second line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients

Int J Clin Oncol　26,P.922-932　/　2021

Tokunaga T, Tanaka M, Tanaka K, Narahara S, Kawasaki T, Yoshimaru Y, Nagaoka K, Watanabe T, Tateyama M, Naoe H, Sasaki Y, Tanaka Y

Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.

Nat Metab　3,P.196-210　/　2021

Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T,Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y, Kawamura. K Y, Tonami K, Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N and Tsujita K.

Liver fibrosis improvement assessed by magnetic resonance elastography and Mac-2-binding protein glycosylation isomer in patients with hepatitis C virus infection receiving direct-acting antivirals.

Hepatol Res　51,P.528-537　/　2021

Chuaypen N, Chittmittrapap S, Avihingsanon A, Siripongsakun S, Wongpiyabovorn J, Tanpowpong N, Tanaka Y, Tangkijvanich P.

Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection.

Infect Dis. 　24,P.1410-1421　/　2021

Chuaypen N, Jinato T, Avihingsanon A, Chirapongsathorn S, Cheevadhanarak S, Nookaew I, Tanaka Y, Tangkijvanich P.J

Prophylactic antiviral therapy for hepatitis B virus surface antigen-positive patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy

Cancer Sci　112,P.1943-1954　/　2021

Yamauchi N, Maruyama D, Choi I, Atsuta Y, Sakai R, Miyashita K, Moriuchi Y, Tsujimura H, Kubota N, Yamamoto G, Igarashi T, Izutsu K, Yoshida S, Kojima K, Uchida T, Inoue Y, Tsukamoto N, Ohtsuka E, Suzuki S, Inaguma Y, Ichikawa S, Gomyo H, Ushijima Y, Nosaka K, Kurata M, Yasuhito Tanaka Y, Ueda R, Mizokami M, Kusumoto S.

Analysis of Hepatitis B virus genotype D in Greenland suggests presence of novel subgenotype .

Front Microbiol　11,P.602296　/　2021

Bernardi Schneider A-de, Hostager R, Krarup H, Børresen M, Tanaka Y, Morriseau T, Osiowy C and Wertheim J-O.

Usefulness of an artificial intelligence system for the detection of esophageal squamous cell carcinoma evaluated with videos simulating overlooking situation

Dig Endosc　33,P.1101-1109　/　2021

Waki K, Ishihara R, Kato Y, Shoji A, Inoue T, Matsueda K, Miyake M, Shimamoto Y, Fukuda H, Matsuura N, Ono Y, Yao K, Hashimoto S, Terai S, Ohmori M, Tanaka K, Kato M, Shono T, Miyamoto H, Tanaka Y, Tada　T

Risk stratification for advanced colorectal neoplasia based on the findings of the index and first surveillance colonoscopies.

PLoS One　16,P.e0245211　/　2021

Honda M, Naoe H, Honda M, Naoe H, Gushima R, Miyamoto H, Tateyama M, Oda Y, Murakami Y, Tanaka Y.

Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients infected patients.

Sci Rep　11,P.960　/　2021

Imahashi M, Ode H, Kobayashi A, Nemoto M, Matsuda M, Hashiba C, Hamano A, Nakata Y, Mori M, Seko K，Nakahata M, Kogure A, Tanaka Y, Sugiura W, Yokomaku Y,Iwatani Y.

Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients.

Hepatol Int　15,P.71-81　/　2021

Liu M, Tseng TC, Jun DW, Yeh ML, Trinh H, Wong GLH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung M, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng CH, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH.

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

J Hepatol　74,P.1075-1086　/　2021

Higashi-Kuwata N, Hayashi S, Kumamoto H, Ogata-Aoki H, Das D , Venzon D, Hattori S, Bulut H, Hashimoto M, Otagiri M, Takamune N, Kishimoto N, Davis A-D, Misumi S, Kakuni, M Tanaka Y, Mitsuya H.

Ten-Eleven Translocation 1 Promotes Malignant Progression of Cholangiocarcinoma With Wild-Type Isocitrate Dehydrogenase 1

Hepatology　73,P.1747-1763　/　2021

Bai X, Zhang H, Zhou Y, Nagaoka K, Ji C, Cao K, Mulla J, Cheng Z, Mueller W, Bay A, Hildebrand G, Lu S, Wallace J, Wands JR, Sun B*, Huang CK*.

Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants.

Clin Gastroenterol Hepatol　19,P.46-60.e8　/　2021

Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey , Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen H, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJ, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y.