Ischemic change in gastric mucosa due to gastric wall expansion with air supply: Real-time capture in upper gastrointestinal endoscopy

Digestive Endoscopy　/　2022

Matsuno K ,Sonoda T, Tanaka Y

Prediction of Sustained Response After Nucleo(s)tide Analogue Cessation Using HBsAg and HBcrAg Levels: A Multicenter Study (CREATE)

Clin Gastroenterol Hepatol　20/P.e784-e793/2022

Milan J Sonneveld 1, Jun Yong Park 2, Apichat Kaewdech 3, Wai-Kay Seto 4, Yasuhito Tanaka 5, Ivana Carey 6, Margarita Papatheodoridi 7, Florian van Bömmel 8, Thomas Berg 8, Fabien Zoulim 9, Sang Hoon Ahn 2, George N Dalekos 10, Nicole S Erler 11, Christoph Höner Zu Siederdissen 12, Heiner Wedemeyer 12, Markus Cornberg 12, Man-Fung Yuen 4, Kosh Agarwal 6, Andre Boonstra 13, Maria Buti 14, Teerha Piratvisuth 3, George Papatheodoridis 7, Benjamin Maasoumy 12; CREATE Study Group

Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma.

Hepatol Res　52,P.93-104　/　2022

Matsui T, Hamada-Tsutsumi S, Naito Y, Nojima M, Iio E, Tamori A, Kubo S, Ide T, Kondo Y, Eguchi Y, Komori A, Morine Y, Shimada M, Utsunomiya T, Shirabe K, Kimura K, Hiasa Y, Chuaypen N, Tangkijvanich P, Ito-Naiki A, Takahashi S, Ochiya T, Tanaka Y.

Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

Clin Gastroenterol Hepatol　20,P.874-885.e4　/　2022

Park J, Le AK, Tseng TC, Yeh ML, Jun DW, Trinh H, Wong G LH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung KS, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH．

Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy: A randomized controlled trial.

Clin Gastroenterol Hepatol　20/P.1394-1403/2022

Kato S, Kuwatani M, Onodera M, Kudo T, Sano I, Katanuma A, Uebayashi M, Eto K, Fukasawa M, Hashigo S, Iwashita T, Yoshida M, Taya Y, Kawakami H, Kato H, Nakai Y, Kobashigawa K, Kawahata S, Shinoura S, Ito K, Kubo K, Yamato H, Hara K, Maetani I, Mukai T, Shibukawa G, Itoi T.

Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection.

Liver Int.　42,P.124-134　/　2022

Inoue T, Funatsu Y, Ohnishi M, Isogawa M, Kawashima K, Tanaka M, Moriya K, Kawaratani H, Momoda R, Iio E, Nakagawa H, Suzuki Y, Matsuura K, Fujiwara K, Nakajima A, Yoshiji H, Nakayama J, Tanaka Y.

Optimal management of lenvatinib therapy for patients with unresectable hepatocellular carcinoma by balancing the therapeutic effect with the relative dose intensity

Hepatol Res　52,P.105-119　/　2022

Tokunaga T, Tateyama M, Tanaka K, Narahara S, Inada H, Kurano S, Hayashi S, Yoshimaru Y, Nagaoka K , Watanabe T,Setoyama H, Tanaka M,　Tanaka Y.

Blocking neddylation elicits antiviral effect against hepatitis B virus replication.

Mol Biol Rep　49,P.403-412　/　2022

Abounouh K, Kayesh MEH, Altawalah H, Kitab B, Murakami S, Ogawa S, Tanaka Y, Dehbi H, Pineau P, Kohara M, Benjelloun S, Tsukiyama-Kohara K, Ezzikouri S.

Time-course changes in liver functional reserve after successful sofosbuvir/velpatasvir treatment in patients with decompensated cirrhosis.

Hepatol Res　52,P.235-246　/　2022

Atsukawa M, Tsubota A, Kondo C, Toyoda H, Nakamuta M, Takaguchi K, Watanabe T, Hiraoka A, Uojima H, Ishikawa T, Iwasa M, Tada T, Nozaki A, Chuma M, Fukunishi S, Asano T, Ogawa C, Abe H, Kato K, Hotta N, Shima T, Matsuura K, Mikami S, Tachi Y, Fujioka S, Okubo H, Shimada N, Tani J, Morishita A, Hidaka I, Moriya A, Tsuji K, Akahane T, Okubo T, Arai T, Kitamura M, Morita K, Kawata K, Tanaka Y, Kumada T, Iwakiri K; KTK49 Liver Study Group.

Endoscopic direct clipping versus indirect clipping for colonic diverticular bleeding: A large multicenter cohort study

United European Gastroenterol J　10,P.93-103　/　2022

Kishino T, Nagata N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kawagishi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Kaise M.

Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019.

Sci Rep.　12,P.1517　/　2022

Nakano M, Yatsuhashi H, Bekki S, Takami Y, Tanaka Y, Yoshimaru Y, Honda K, Komorizono Y, Harada M, Shibata M, Sakisaka S, Shakado S, Nagata K, Yoshizumi T, Itoh S, Sohda T, Oeda S, Nakao K, Sasaki R, Yamashita T, Ido A, Mawatari S, Nakamuta M, Aratake Y, Matsumoto S, Maeshiro T, Goto T, Torimura T.

Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels.

J Hepatol.　S0168-8278(22)00020-4.　/　2022

Sonneveld MJ, Chiu SM, Park JY, Brakenhoff SM, Kaewdech A, Seto WK, Tanaka Y, Carey I, Papatheodoridi M, van Bömmel F, Berg T, Zoulim F, Ahn SH, Dalekos GN, Erler NS, Höner Zu Siederdissen C, Wedemeyer H, Cornberg M, Yuen MF, Agarwal K, Boonstra A, Buti M, Piratvisuth T, Papatheodoridis G, Chen CH, Maasoumy B; CREATE study group.

Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application

Sci Rep　12/P.2133-/2022

Hayashi S, Isogawa M, Kawashima K, Ito K, Natthaya Chuaypen N, Morine Y, Shimada　M, Higashi-Kuwata N, Watanabe T, Tangkijvanich P, Mitsuya H, Tanaka Y

Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B

PLoS One　17/P.e0263844-/2022

Yoshihito Nagura 1 2, Kentaro Matsuura 2, Etsuko Iio 1, Koji Fujita 3, Takako Inoue 4, Akihiro Matsumoto 5, Eiji Tanaka 5, Shuhei Nishiguchi 6, Jong-Hon Kang 7, Takeshi Matsui 7, Masaru Enomoto 8, Hiroki Ikeda 9, Tsunamasa Watanabe 9, Chiaki Okuse 10, Masataka Tsuge 11, Masanori Atsukawa 12, Masakuni Tateyama 13, Hiromi Kataoka 2, Tanaka Y

Management of hepatitis B virus (HBV) reactivation in patients with resolved HBV infection based on a highly sensitive HB core-related antigen assay.

Hepatol Res　/　2022

Hagiwara S, Kusumoto S, Inoue T, Ogawa S, Narita T, Ito A, Ri M, Komatsu H, Suzuki T, Matsuura K, Yagi S, Kaneko A, Aoyagi K, Iida S, Tanaka Y.

Mac-2 Binding Protein Glycosylation isomer (M2BPGi) to evaluate liver fibrosis and cancer in HBV-infected patients in West Africa

J Glob Health　/　2022

Vincent JP, Ndow G, Ogawa S, Ceesay A, Njie R, Sanneh B, Baldeh I, D’Alessandro U, Mendy M, Thursz M, Chemin I, Tanaka Y, Lemoine M, Shimakawa Y

Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay to determine the initiation of treatment for HBV reactivation

J　Gastroenterol　/　2022

Suzuki T,Inoue T,Matsuura K,Kusumoto S,Hagiwara S,Ogawa S,Yagi S,Kaneko A,Fujiwara K,Watanabe T,Aoyagi K,Urata Y,Tamori A,Kataoka H,Tanaka Y

Ischemic change in gastric mucosa due to gastric wall expansion with air supply: Real-time capture in upper gastrointestinal endoscopy

Digestive Endoscopy　/　2022

Matsuno K ,Sonoda T, Tanaka Y

Rapid point-of-care test for hepatitis B core-related antigen to diagnose high viral load in resource-limited settings

Clin Gastroenterol Hepatol　/　2022

Shimakawa Y, Gibril Ndow,3,4 Théo Cerceau,1 Amie Ceesay,3 Atsushi Kaneko,5 Akira Hasegawa,5 Naoki Yamamoto,5 Katsumi Aoyagi,5 Jeanne Perpétue Vincent,1 Takehisa Watanabe,6 Masaya Baba,2 Bakary Sanneh,7 Ignatius Baldeh,7 Ramou Njie,8,9 Umberto D’Alessandro,3 Maimuna Mendy,10 Isabelle Chemin,11 Mark R. Thursz,4 Maud Lemoine,4 and Tanaka Y

Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy

J Hepatol　77,P.967-977　/　2022

Yuen M-F, Heo J, Kumada H, Suzuki F, Suzuki Y, Xie Q, Jia J, Karino Y, Hou J, Chayama K, Imamura M, Lao-Tan J-Y, Lim S-G, Tanaka Y, Xie W, Yoon J-H, Duan Z, Kurosaki M, Sung-Park J, Labio M-E, Kumar R, Kweon Y-O, Yim H-J, Tao Y, Cremer J, Elston R, Davies M, Baptiste-Brown S, Han K, Campbell F-M, Paff M, Theodore D.

The impact of the covalently closed circular DNA level on recurrence of hepatocellular carcinoma after initial hepatectomy: an analysis of patients with resolved hepatitis B virus infection

HPB (Oxford)　24/P.1780-1788/2022

Sung Kwan Bae 1, Junichi Arita 1, Nobuhisa Akamatsu 1, Harufumi Maki 1, Yujiro Nishioka 1, Takuya Kawahara 2, Akinori Miyata 1, Takashi Kokudo 1, Rihito Nagata 1, Yuichiro Mihara 1, Akihiko Ichida 1, Yoshinori Inagaki 1, Yoshikuni Kawaguchi 1, Takeaki Ishizawa 1, Junichi Kaneko 1, Sumihito Tamura 1, Tanaka Y , Kyoji Moriya 4, Kiyoshi Hasegawa 5

Drug Discovery Study Aimed at a Functional Cure for HBV

Viruses 　14/P.1393-/2022

Watanabe T, Hayashi S, Tanaka Y

Serum angiopoietin-2 levels predict regression of Mac-2 binding protein glycosylation isomer-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents.

Hepatol Res　52/P.919-927/2022

Suzuki T, Matsuura K,Nagura Y, Ogawa S,Fujiwara K,Nojiri S,Watanabe T, Kataoka H,Tanaka Y

DEB-TACE combined with hepatic artery infusion chemotherapy might be an affordable treatment option for advanced stage of HCC.

Sci Rep　12/P.16868-/2022

Kondo Y,Morosawa T,Minami S, Tanaka Y

Comparison of Efficacy and Safety of Atezolizumab Plus Bevacizumab and Lenvatinib as First-Line Therapy for Unresectable Hepatocellular Carcinoma: A Propensity Score Matching Analysis.

Target Oncol.　17/P.643-653/2022

Niizeki T, Tokunaga T, Takami Y, Wada Y, Harada M, Shibata M, Nakao K, Sasaki R, Hirai F, Shakado S, Yoshizumi T, Itoh S, Yatsuhashi H, Bekki S, Ido A, Mawatari S, Honda K, Sugimoto R, Senju T, Takahashi H, Kuwashiro T, Maeshiro T, Nakamuta M, Aratake Y, Yamashita T, Otsuka Y, Matsumoto S, Sohda T, Shimose S, Murotani K, Tanaka Y.

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.

N Engl J Med　24/P.1957-1968/2022

Yuen MF, Lim SG, Plesniak R, Tsuji K, Janssen HLA, Pojoga C, Gadano A, Popescu CP, Stepanova T, Asselah T, Diaconescu G, Yim HJ, Heo J, Janczewska E, Wong A, Idriz N, Imamura M, Rizzardini G, Takaguchi K, Andreone P, Arbune M, Hou J, Park SJ, Vata A, Cremer J, Elston R, Lukić T, Quinn G, Maynard L, Kendrick S, Plein H, Campbell F, Paff M, Theodore D; B-Clear Study Group (Collaborators)

Ivermectin Inhibits HBV Entry into the Nucleus by　Suppressing KPNA2

Viruses 　14/P.2468-/2022

Anna Nakanishi , Hiroki Okumura , Tadahiro Hashita , Aya Yamashita , Yuka Nishimura ,Chihiro Watanabe , Sakina Kamimura, Sanae Hayashi , Shuko Murakami , Kyoko Ito , Takahiro Iwao ,Akari Ikeda 5, Tomoyasu Hirose , Toshiaki Sunazuka , Tanaka Y * and Tamihide Matsunaga

Mac-2-Binding Protein Glycan Isomer Predicts All Malignancies Post-sustained Virological Response in Chronic Hepatitis C

Hepatol Commun　/　2022

Kawata K, Atsukawa M, Ohta K, Chida T, Noritake H, Arai T, Iwakiri K, Yasuda S, Toyoda H, Okubo T, Hiraoka A, Watanabe T, Uojima H, Nozaki A, Tani J, Morishita A, Kageyama F, Sasada Y, Nagasawa M, Matsushita M, Oyaizu T, Mikami S, Ikegami T, Abe H, Matsuura K, Tanaka Y, Tsubota A

Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model

Front. Virol　/　2022

Kayesh M-E-H, Hashem M-A, Sanada T, Kitab B, Rashid M-H-O, Akter L, Ezzikouri S, Murakami S, Ogawa S, Tanaka Y, Kohara M and Tsukiyama-Kohara K

Mixed Neuroendocrine Non-Neuroendocrine Neoplasm Arising in the Ectopic Gastric Mucosa of Esophagus

Case Rep Gastroenterol　16/P.637-945/2022

Gushima R, Miyamoto H, Imamura M, Sonoda T, Matsuno K, Yamasaki A, Furuta Y, Hashigo S, Tateyama M, Naoe H, Tanaka Y

The Impact of Cirrhosis and History of Hepatocellular Carcinoma on All-Cause Mortality After Eradication of Hepatitis C Virus in Patients With Chronic Hepatitis C

Gastro Hep Advances　1/P.508-515/2022

Toyoda H, Atsukawa M, Uojima H, Nozaki A, Takaguchi K, Hiraoka A, Itobayashi E, Watanabe T, Matsuura K, Shimada N, Abe H,Tsuji K, Itokawa N, Mikami S, Ishikawa T,Oikawa T,Yasuda S, Chuma M,Tsutsui A,Ikeda H, Arai T,Tsubota A,Kumada T,Tanaka Y,Tanaka J