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Research & achievements研究・業績

Research paper

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  • 研究活動

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2022年度英文

  • 英文 原著他 (PubMed順)2022年度

    Ischemic change in gastric mucosa due to gastric wall expansion with air supply: Real-time capture in upper gastrointestinal endoscopy

    Digestive Endoscopy / 2022

  • 英文 原著他 (PubMed順)2021年度

    Case of hepatitis B virus reactivation after ibrutinib therapy in which the patient remained negative for hepatitis B surface antigens throughout the clinical course

    Hepatol Res 51,P.239-244 / 2021

    Huge hepatocellular carcinoma with extrahepatic collateral arteries successfully treated by multidisciplinary treatment including laparoscopic devascularization: a case report.

    Clin J Gastroenterol 14,P.251-257 / 2021

    Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage.

    Anticancer Res 41,P.2727-2732 / 2021

    Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor.

    Anticancer Res 41,P.5249-5254 / 2021

    Mac-2 binding protein and its glycan isomer: Where does it come from? Where is it going?

    Hepatol Res 51,P.1026-1028 / 2021

    Exosomal circCMTM3 promotes the pathogenesis of hepatocellular carcinoma via angiogenesis.

    Hepatol Res 51,P.1100-1101 / 2021

    Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy.

    Anticancer Res 41,P.5855-5861 / 2021

    A female patient with GSD IXc developing multiple and recurrent hepatocellular carcinoma: a case report and literature review.

    Hum Genome Var 8,P.45 / 2021

    "Improved visibility of early gastric cancer using a combination of chromoendoscopy and Texture and Color Enhancement Imaging"

    Gastrointest Endosc S0016-5107(21)01930-1. / 2021

  • 英文 原著他 (PubMed順)2020年度

    Successful treatment of occult pancreatic melanoma using BRAF/MEK inhibitors.

    J Dermatol 47,P.e126-e147 / 2020

    Successful treatment of adult-onset type II citrullinemia with a low-carbohydrate diet and L-arginine after DNA analysis produced a definitive diagnosis

    Clin J Gastroenterol 13,P.823-833 / 2020

    Cytomegalovirus enterocolitis in a patient with refractory immune-related colitis.

    Case Rep Gastroenterol 14,P.103-109 / 2020

    Hepatitis B virus reactivation in a myeloma patient with resolved infection who received daratumumab-containing salvage chemotherapy

    J Clin Exp Hematop 60,P.51-54 / 2020

    Multiple Gastric Polyps Improved After Treatment for Ulcerative Colitis.

    Inflamm Bowel Dis 26,P.e144-e145 / 2020

    Sjögren's Syndrome as an Immune-related Adverse Event of Nivolumab Treatment for Gastric Cancer

    Intern Med 59,P.2499-2504 / 2020

    Complete Removal of Adrenal Metastasis in Hepatocellular Carcinoma Using Indocyanine Green Fluorescent Imaging.

    Anticancer Res 40,P.5823-5828 / 2020

    Hepatocellular Carcinoma With Extensive Cancer-associated Thrombosis Successfully Treated With Liver Resection and Direct Oral Anticoagulant: A Case Report.

    Anticancer Res 40,P.6465-6471 / 2020

    Cholangiolocarcinoma With Multiple Recurrences Successfully Treated With Repeated Liver Resection and Radiofrequency Ablation.

    Anticancer Res 40,P.7147-7153 / 2020

  • 英文 原著他 (PubMed順)2019年度

    Nivolumab-induced colitis in a patient with malignant melanoma: A case report and immunological analysis.

    J Dermatol 46,P.e339-e341 / 2019

    Hepatitis C virus recurrence in two patients who achieved sustained viral response with interferon-free direct-acting antiviral therapy: reinfection or relapse?

    Clin J Gastroenterol 12,P.598-302 / 2019

  • 英文 原著他 (PubMed順)2018年度

    Advanced parametric imaging for evaluation of Crohn’s disease using dual-energy computed tomography enterography.

    Radiol Case Rep 13,P.709-712 / 2022

  • 英文(PubMed順) 2022年度

    Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model

    Front. Virol / 2022

    Mac-2 Binding Protein Glycosylation isomer (M2BPGi) to evaluate liver fibrosis and cancer in HBV-infected patients in West Africa

    J Glob Health / 2022

    Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy

    J Hepatol 77,P.967-977 / 2022

    Ischemic change in gastric mucosa due to gastric wall expansion with air supply: Real-time capture in upper gastrointestinal endoscopy

    Digestive Endoscopy / 2022

    Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy

    J Hepatol / 2022

    Rapid point-of-care test for hepatitis B core-related antigen to diagnose high viral load in resource-limited settings

    Clin Gastroenterol Hepatol / 2022

    Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay to determine the initiation of treatment for HBV reactivation

    J Gastroenterol / 2022

    Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels.

    J Hepatol. S0168-8278(22)00020-4. / 2022

    Management of hepatitis B virus (HBV) reactivation in patients with resolved HBV infection based on a highly sensitive HB core-related antigen assay.

    Hepatol Res / 2022

    Blocking neddylation elicits antiviral effect against hepatitis B virus replication.

    Mol Biol Rep 49,P.403-412 / 2022

    Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection.

    Liver Int. 42,P.124-134 / 2022

    Time-course changes in liver functional reserve after successful sofosbuvir/velpatasvir treatment in patients with decompensated cirrhosis.

    Hepatol Res 52,P.235-246 / 2022

    Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019.

    Sci Rep. 12,P.1517 / 2022

    Mac-2-Binding Protein Glycan Isomer Predicts All Malignancies Post-sustained Virological Response in Chronic Hepatitis C

    Hepatol Commun / 2022

    Endoscopic direct clipping versus indirect clipping for colonic diverticular bleeding: A large multicenter cohort study

    United European Gastroenterol J 10,P.93-103 / 2022

    Optimal management of lenvatinib therapy for patients with unresectable hepatocellular carcinoma by balancing the therapeutic effect with the relative dose intensity

    Hepatol Res 52,P.105-119 / 2022

    Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.

    Clin Gastroenterol Hepatol 20,P.874-885.e4 / 2022

    Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma.

    Hepatol Res 52,P.93-104 / 2022

  • 英文(PubMed順) 2021年度

    Development of hepatocellular carcinoma from various phases of chronic hepatitis B virus infection.

    PLoS One 16,P.e0261878 / 2021

    Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR.

    Cancers (Basel). 13,P.3455 / 2021

    The risk of cirrhosis and its complications based on PNPLA3 rs738409 G allele frequency.

    Dig Dis / 2021

    A novel noninvasive formula for predicting cirrhosis in patients with chronic hepatitis C.

    PLoS One.  16,P.e0257166 / 2021

    Long-term outcomes after endoscopic resection for late elderly patients with early gastric cancer

    Gastrointest Endosc S0016-5107(21)01942-8. / 2021

    Treatment strategies for reducing early and late recurrence of colonic diverticular bleeding based on stigmata of recent hemorrhage: a large multicenter study

    Gastrointest Endosc S0016-5107(21)01937-4 / 2021

    Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study

    BMC Gastroenterol 21,P.489 / 2021

    Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma

    Hepatol Commun 2021 Nov 27. doi: 10.1002/hep4.1872. / 2021

    Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study

    World J Gastrointest Endosc 13,P.491-501 / 2021

    Hepatitis B Core-Related Antigen and New Therapies for Hepatitis B

    microorganisms 9,P.2083 / 2021

    Blood‐Based Biomarkers in Hepatitis B Virus‐Related Hepatocellular Carcinoma, Including the Viral Genome and Glycosylated Proteins

    Int. J. Mol. Sci 22,P.11051 / 2021

    All-atom molecular dynamics study of hepatitis B virus containing pregenome RNA in solution

    J Chem Phys 155,P.145101 / 2021

    Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

    Sci Rep 11,P.20373 / 2021

    Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy: A randomized controlled trial.

    Clin Gastroenterol Hepatol S1542-3565(21)00872-7. / 2021

    Identifying Bleeding Etiologies by Endoscopy Affected Outcomes in 10,342 Cases With Hematochezia: CODE BLUE-J Study

    Am J Gastroenterol 116,P.2222-2234 / 2021

    A Genome-Wide Association Study Identifying SVEP1 Variant as a Predictor of Response to Tolvaptan for Cirrhotic Ascites.

    Liver Int 41,P.2944-2953 / 2021

    N-glycan structures of Wisteria floribunda agglutinin-positive Mac2 binding protein in the serum of patients with liver fibrosis.

    Glycobiology 31,P.1268-1278 / 2021

    Application of Fluorescent-Based Technology Detecting Protein-Protein Interactions to Monitor the Binding of Hepatitis B Virus X protein to DNA-damage-binding protein 1.

    BPPB 18,P.67-77 / 2021

    Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA.

    Sci Rep 11,P.8672 / 2021

    Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation.

    J Hepatol 75,P.302-310 / 2021

    Modifed albumin–bilirubin grade to predict eligibility for second line therapies at progression on sorafenib therapy in hepatocellular carcinoma patients

    Int J Clin Oncol 26,P.922-932 / 2021

    Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.

    Nat Metab 3,P.196-210 / 2021

    Liver fibrosis improvement assessed by magnetic resonance elastography and Mac-2-binding protein glycosylation isomer in patients with hepatitis C virus infection receiving direct-acting antivirals.

    Hepatol Res 51,P.528-537 / 2021

    Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection.

    Infect Dis.  24,P.1410-1421 / 2021

    Prophylactic antiviral therapy for hepatitis B virus surface antigen-positive patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy

    Cancer Sci 112,P.1943-1954 / 2021

    Analysis of Hepatitis B virus genotype D in Greenland suggests presence of novel subgenotype .

    Front Microbiol 11,P.602296 / 2021

    Usefulness of an artificial intelligence system for the detection of esophageal squamous cell carcinoma evaluated with videos simulating overlooking situation

    Dig Endosc 33,P.1101-1109 / 2021

    Risk stratification for advanced colorectal neoplasia based on the findings of the index and first surveillance colonoscopies.

    PLoS One 16,P.e0245211 / 2021

    Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients infected patients.

    Sci Rep 11,P.960 / 2021

    Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients.

    Hepatol Int 15,P.71-81 / 2021

    Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

    J Hepatol 74,P.1075-1086 / 2021

    Ten-Eleven Translocation 1 Promotes Malignant Progression of Cholangiocarcinoma With Wild-Type Isocitrate Dehydrogenase 1

    Hepatology 73,P.1747-1763 / 2021

    Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants.

    Clin Gastroenterol Hepatol 19,P.46-60.e8 / 2021

  • 英文(PubMed順) 2018年度

    Impact of retroflexion in the right colon after repeated forward-view examinations.

    JGH open 2,P.282-287 / 2018

    Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

    Transplant Proc 50,P.3858-3862 / 2018

    Circulating let-7 Levels in Serum Correlate With the Severity of Hepatic Fibrosis in Chronic Hepatitis C.

    Open Forum Infect Dis 5,P.ofy268 / 2018

    Serum M2BPGi level and risk of hepatocellular carcinoma after oral anti-viral therapy in patients with chronic hepatitis B

    Aliment Pharmacol Ther 48,P.1128-1137 / 2018

    Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer.

    Oncol Lett 16,P.5275-5281 / 2018

    Type I interferon signaling prevents hepatitis B virus-specific T cell responses by reducing antigen expression

    J Virol 92,P.e01099 / 2018

    Intrahepatic Cross-Presentation and Hepatocellular Antigen Presentation Play Distinct Roles in the Induction of Hepatitis B Virus-Specific CD8 + T Cell Responses

    J Virol 92,P.e01099 / 2018

    Screening of microRNAs for a repressor of hepatitis B virus replication

    Oncotarget 9,P.29857-29868 / 2018

    Sofosbuvir–velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who failed direct-acting antivirals

    Hepatol Int 12,P.356-367 / 2018

    Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment.

    Cancer Lett 434,P.91-100 / 2018

    Clinical evaluation of a novel and highly sensitive immunoassay for anti-hepatitis B core antigen using a fully automated immunochemical analyzer

    Hepatol Res 48,P.1081-1091 / 2018

    Suppression of hepatitis B surface antigen production by combination therapy with nucleotide analogues and interferon in children with genotype C hepatitis B virus infection

    Hepatol Res 48,P.1172-1177 / 2018

    De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry

    Cell Chem Biol 25,P.906-915. e7 / 2018

    Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells

    Mol Ther 26,P.1840-1854 / 2018

    Real-world virological efficacy and safety of elbasvir and grazoprevir in patients with chronic hepatitis C virus genotype 1 infection in Japan

    J Gastroenterol 53,P.1276-1284 / 2018

    Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein level as a diagnostic marker of hepatitis B virus-related hepatocellular carcinoma

    Hepatol Res 48,P.872-881 / 2018

    Gut dysbiosis associated with hepatitis C virus infection

    Clin Infect Dis 67,P.869-877 / 2018

    Efficacy and safety of ledipasvir/sofosbuvir for genotype 1b chronic hepatitis C patients with moderate renal impairment

    Hepatol Int 12,P.133-142 / 2018

    Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.

    CPT Pharmacometrics Syst Pharmacol 7,P.384-393 / 2018

    Efficacy and safety of ombitasvir/paritaprevir/ritonavir combination therapy for genotype 1b chronic hepatitis C patients complicated with chronic kidney disease

    Hepatol Res 48,P.549-555 / 2018

    Vonoprazan is Superior to Rabeprazole for Healing Endoscopic Submucosal Dissection: Induced Ulcers

    Hepatol Res 97,P.170-176 / 2018

    High levels of serum Mac-2-binding protein glycosylation isomer (M2BPGi) predict the development of hepatocellular carcinoma in hepatitis B patients treated with nucleot(s)ide analogues

    J Gastroenterol 53,P.883-889 / 2018

    Antiviral therapy for hepatitis B virus during second pregnancies

    J Obstet Gynaecol Res 44,P.566-569 / 2018

    Late relapse after a sustained virologic response at 24 weeks after treatment with daclatasvir and asunaprevir combination therapy for chronic hepatitis c virus genotype 1b infection with liver cirrhosis

    Intern Med 57,P.951-956 / 2018

    Changes in serum lipid profiles caused by three regimens of interferon-free direct-acting antivirals for patients infected with hepatitis C virus

    Hepatol Res 48,P.E203-E212 / 2018

    Predictive role of serum HBsAg and HBcrAg kinetics in patients with HBeAg-negative chronic hepatitis B receiving pegylated interferon–based therapy

    Clin Microbiol Infect 24,P.306. e7-306. e13 / 2018

    Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease

    J Gastroenterol 53,P.438-448 / 2018

    Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy.

    J Gastroenterol 53,P.247-257 / 2018

    Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: a nationwide retrospective study in Japan

    J Gastroenterol 53,P.119-128 / 2018

    Effect of hepatitis B virus subgenotype on antiviral response in nucleoside-treated hepatitis B envelope antigen-positive patients

    Hepatol Res 48,P.134-143 / 2018

  • 英文(PubMed順) 2020年度

    HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort

    Hepatol Int 14,P.1023-1033 / 2020

    Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study.

    BMC Gastroenterol 20,P.371 / 2020

    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.

    Cell Rep 33,P.108265 / 2020

    Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

    Virus Res 290,P.198191 / 2020

    Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture

    Int. J. Mol. Sci 21,P.7251 / 2020

    Pancreatic neuroendocrine carcinoma G3 may be heterogeneous and could be classified into two distinct groups.

    Pancreatology 20,P.1421-1427 / 2020

    Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus

    Hepatol Res 50,P.1128-1140 / 2020

    Hepatitis B surface antigen, core-related antigen and HBV RNA: Predicting clinical relapse after NA therapy discontinuation.

    Liver Int 40,P.2961-2971 / 2020

    Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis

    Dig Dis Sci. 66,P.1080-1089 / 2020

    Baseline Mac-2 Binding Protein Glycosylation Isomer Level Stratifies Risks of Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Oral Antiviral Therapy

    Liver Cancer 9,P.207-220 / 2020

    The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism

    Liver Research 9,P.94-100 / 2020

    "Ultra-high sensitivity HBsAg assay can diagnose HBV reactivation following rituximab-based therapy in patients with lymphoma"

    J Hepatol 73,P.285-293 / 2020

    Fluorescence-based biochemical analysis of human hepatitis B virus reverse transcriptase activity

    Anal Biochem 597,P.113642 / 2020

    Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions.

    Sci Rep 10,P.4313 / 2020

    Prometastatic Secretome Trafficking via Exosomes Initiates Pancreatic Cancer Pulmonary Metastasis.

    Cancer Lett 481,P.63-75 / 2020

    The effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients with refractory factors in the real world:

    Hepatol Int 14,P.225-238 / 2020

    A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.

    Diabetes Metab Syndr Obes 13,P.333-341 / 2020

    7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

    Antiviral Res 176,P.104744 / 2020

    JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study.

    J Gastroenterol 55,P.640-652 / 2020

    Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

    Hepatol Commun 4,P.255-267 / 2020

    Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.

    J Gastroenterol Hepatol 35,P.1420-1425 / 2020

    MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion.

    Cancer Sci 111,P.869-880 / 2020

    Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.

    Carcinogenesis 41,P.1145-1157 / 2020

    HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication.

    Clin Infect Dis 71,P.2840-2848 / 2020

    Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study).

    Gastrointest Endosc 91,P.373-381.e2. / 2020

    Tenofovir versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B

    Am J Gastroenterol 115,P.271-280 / 2020

    Cure with Interferon Free DAA is Associated with Increased Survival in Patients with HCV related HCC from both East and West.

    Hepatology 71,P.1910-1922 / 2020

    Real-world experience of 12-week DAA regimen of glecaprevir and pibrentasvir in patients with chronic HCV infection.

    J Gastroenterol Hepatol 35,P.855-861 / 2020

    Risk stratification of advanced colorectal neoplasia after baseline colonoscopy: Cohort study of 17 Japanese community practices.

    Dig Endosc 32,P.106-113 / 2020

    Endoscopic features of esophageal adenocarcinoma derived from short-segment versus long-segment Barrett’s esophagus

    J Gastroenterol Hepatol 35,P.211-217 / 2020

  • 英文(PubMed順) 2019年度

    Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease.

    PLoS One 14,P.e0224184 / 2019

    Hepatitis B virus-related hepatocellular carcinoma in young adults Efficacy of nationwide selective vaccination.

    Hepatol Res 50,P.182-189 / 2019

    Factors associated with longitudinal changes in serum concentrations of Mac-2 binding protein: a prospective 3-year observational study

    Nutr Metab Cardiovasc Dis 29,P.1337-1344 / 2019

    Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

    J Hematol Oncol. 12,P.144-144 / 2019

    The reduction of miR146b-5p in monocytes and T cells could contribute to the immunopathogenesis of hepatitis C virus infection.

    Sci Rep 9,P.13393 / 2019

    Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium

    Hepatol Int 13,P.587-598 / 2019

    MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells

    Cell Death Dis 10,P.553 / 2019

    Evaluation of 8-week glecaprevir/pibrentasvir treatment in direct-acting antiviral-naïve noncirrhotic HCV genotype 1 and 2infected patients in a real-world setting in Japan.

    J Viral Hepat 26,P.1266-1275 / 2019

    Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV-infected patients with chronic liver disease and thrombocytopenia

    Exp. Ther. Med 18,P.596-604 / 2019

    Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.

    Antiviral Res 169,P.104537 / 2019

    Trends and Efficacy of Interferon-Free Anti–hepatitis C Virus Therapy in the Region of High Prevalence of Elderly Patients, Cirrhosis, and Hepatocellular Carcinoma: A Real-World, Nationwide, Multicenter Study of 10 688 Patients in Japan

    Open Forum Infect Dis 6,P.ofz185 / 2019

    Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production

    J Virol 93,P.e00621 / 2019

    Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma

    Cancer Lett 449,P.87-98 / 2019

    Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis

    J Hepatol 71,P.473-485 / 2019

    Mac-2 Binding Protein Glycosylation Isomer as a Hepatocellular Carcinoma Marker in Patients With Chronic Hepatitis B or C Infection

    Hepatol Commun 3,P.493-503 / 2019

    Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

    Proc Natl Acad Sci U S A 116,P.8487-8492 / 2019

    Clinical evaluation of a newly developed chemiluminescent enzyme immunoassay in Japan for hepatitis C virus core antigen.

    Jpn J Infect Dis 72,P.285-291 / 2019

    The efficacy and safety of glecaprevir plus pibrentasvir in 141 patients with severe renal impairment: a prospective, multicenter study.

    Aliment Pharmacol Ther 49,P.1230-1241 / 2019

    Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately. A

    Ann Surg Oncol 26,P.1385-1393 / 2019

    The antiviral effects of human microRNA miR-302c-3p against hepatitis B virus infection.

    Aliment Pharmacol Ther 49,P.1060-1070 / 2019

    CMCDG, a novel nucleoside analog with favorable safety features, exerts potent activity against wild-type and entecavir-resistant hepatitis B virus

    Antimicrob Agents Chemother 63,P.e02143 / 2019

    Influence of renal dysfunction on dose reduction and virologic efficacy of regimens combining ribavirin and all-oral direct acting antivirals in patients with chronic hepatitis C virus infection

    Hepatol Res 49,P.512-520 / 2019

    Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma

    J Gastroenterol 54,P.427-436 / 2019

    Combining hepatitis B core-related and surface antigens at end of nucleos(t)ide analogue treatment to predict off-therapy relapse risk

    Aliment Pharmacol Ther 49,P.107-115 / 2019

    TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus by interferon-free therapy

    J Gastroenterol 54,P.339-346 / 2019

    Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy

    Blood 133,P.137-146 / 2019

    Efficacy of direct-acting antiviral treatment in patients with compensated liver cirrhosis: A multicenter study

    Hepatol Res 49,P.125-135 / 2019

    Efficacy and safety of sofosbuvir–velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial

    J Gastroenterol 54,P.87-95 / 2019

    Efficacy and safety of elbasvir/grazoprevir for Japanese patients with genotype 1b chronic hepatitis C complicated by chronic kidney disease, including those undergoing hemodialysis: A post hoc analysis of a multicenter study

    J Gastroenterol Hepatol 34,P.364-369 / 2019

    An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

    Hepatology 69,P.19-33 / 2019

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ⓒ Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University