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    Modifed albumin–bilirubin grade to predict eligibility for second line therapies at progression on sorafenib therapy in hepatocellular carcinoma patientsInternational Journal of Clinical Oncology DOI 10.1007/s10147-020-01835-2

    Takayuki Tokunaga, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Takeshi Kawasaki, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Masakuni Tateyama, Hideaki Naoe, Yutaka Sasaki, Yasuhito Tanaka

    Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study.BMC Gastroenterol. 2020, 20, 371.

    Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Kentaro Tanaka, Satoshi Narahara, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Hiroko Setoyama, Yutaka Sasaki, Yasuhito Tanaka. 

    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.Cell Rep. 2020, 33; 108265.

    Tomoaki Inazumi, Kiyotaka Yamada, Naritoshi Shirata, Hiroyasu Sato, Yoshitaka Taketomi, Kazunori Morita, Hirofumi Hohjoh, Soken Tsuchiya, Kentaro Oniki, Takehisa Watanabe, Yutaka Sasaki, Yuichi Oike, Yasuhiro Ogata, Junji Saruwatari, Makoto Murakami, Yukihiko Sugimoto.

    Prometastatic secretome trafficking via exosomes initiates pancreatic cancer pulmonary metastasis.Cancer Lett. 2020 Jul 1; 481:63-75.

    Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands JR, Dong X.

    Successful treatment of occult pancreatic melanoma using BRAF/MEK inhibitors.J Dermatol. 2020 Apr;47(4): e126-e127.

    Mizukami Y, Kanemaru H, Nakamura K, Hashigo S, Kajihara I, Miyashita A, Aoi J, Fukushima S, Honda Y, Ihn H.

    Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study).Gastrointest Endosc. 2020 Feb;91(2):373-381.

    Kurita A, Yasukawa S, Zen Y, Yoshimura K, Ogura T, Ozawa E, Okabe Y, Asada M, Nebiki H, Shigekawa M, Ikeura T, Eguchi T, Maruyama H, Ueki T, Itonaga M, Hashimoto S, Shiomi H, Minami R, Hoki N, Takenaka M, Itokawa Y, Uza N, Hashigo S, Yasuda H, Takada R, Kamada H, Kawamoto H, Kawakami H, Moriyama I, Fujita K, Matsumoto H, Hanada K, Takemura T, Yazumi S.

    Risk stratification of advanced colorectal neoplasia after baseline colonoscopy: Cohort study of 17 Japanese community practices.Digestive endoscopy. 2020; 32(1):106-113

    Shono T, Oyama S, Oda Y, Yokomine K, Murakami Y, Miyamoto H, Tanaka M, Naoe H, Sasaki Y, Kumamoto Colon Cancer, Study Group.

    Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis.Case Rep Gastroenterol. 2020;14:103–109

    Furuta Y, Miyamoto H, Naoe H, Shimoda M, Hinokuma Y, Tanaka M, Sasaki Y.

    A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.Diabetes Metab Syndr Obes. 2020 Feb 12; 13: 333-341

    Muto N, Oniki K, Kudo M, Obata Y, Sakamoto Y, Tokumaru N, Izuka T, Watanabe T, Otake K, Ogata Y, Saruwatari J.

    Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions. Sci Reports. 2020 Mar 9; 10(1): 4313

    Oniki K, Kawakami T, Nakashima A, Miyata K, Watanabe T, Fujikawa H, Nakashima R, Nasu A, Eto Y, Takahashi N, Nohara H, Suico MA, Kotani S, Obata Y, Sakamoto Y, Seguchi Y, Sarauwatari J, Imafuku T, Watanabe H, Maruyama T, Kai H, Shuto T.

    Endoscopic features of esophageal adenocarcinoma derived from short-segment versus long-segment Barrett’s esophagus. J Gastroenterol Hepatol 2020: 35:211–217

    Yamasaki A, Shimizu T, Kawachi H, Yoshimizu S, Horiuchi Y, Ishiyama A, Yoshio T, Hirasawa T, Tsuchida T, Sasaki Y, Fujisaki J.

    Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway. J Hematol Oncol. 2019 Dec 30;12(1):144.

    Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands JR, Dong X.

    Endoscopic ultrasound findings and pathological features of pancreatic carcinoma in situ.Endosc Int Open. 2019 Apr;7(4): E585-E593

    Izumi Y, Hanada K, Okazaki A, Minami T, Hirano N, Ikemoto J, Kanemitsu K, Nakadoi K, Shishido T, Katamura Y, Onogawa S, Amano H, Hino F, Amano H, Yonehara S.

    Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately. Ann Surg Oncol. 2019 May;26(5):1385-1393.

    Yoshida T, Hijioka S, Hosoda W, Ueno M, Furukawa M, Kobayashi N, Ikeda M, Ito T, Kodama Y, Morizane C, Notohara K, Taguchi H, Kitano M, Yane K, Tsuchiya Y, Komoto I, Tanaka H, Tsuji A, Hashigo S, Mine T, Kanno A, Murohisa G, Miyabe K, Takagi T, Matayoshi N, Sakaguchi M, Ishii H, Kojima Y, Matsuo K, Yoshitomi H, Nakamori S, Yanagimoto H, Yatabe Y, Furuse J, Mizuno N.

    Post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones. J Gastroenterol Hepatol. 2019; 34(7): 1153-1159

    Saito H, Koga T, Sakaguchi M, Kadono Y, Kamikawa K, Urata A, Imamura H, Tada S, Kakuma T, Matsushita I.

    Anti-tumor activity of antibody drug conjugateCancer Lett. 2019 May 1; 449:87-98.

    Nagaoka K, Bai X, Ogawa K, Dong X, Zhang S, Zhou Y, Carlson RI, Jiang ZG, Fuller S, Lebowitz MS, Ghanbari H, Wands JR.

    Safety and Efficacy of Endoscopic Removal of Common Bile Duct Stones in Elderly Patients ≥90 Years of Age.Intern Med. 2019; 58(15): 2125-2132

    Saito H, Koga T, Sakaguchi M, Kadono Y, Kamikawa K, Urata A, Imamura H, Tada S, Kakuma T, Matsushita I.

    Risk factors for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones. World J Gastrointest Endosc. 2019; 11(10): 515-522

    Saito H, Kakuma T, Matsushita I.

    Lysine-specific demethylase-2 is distinctively involved in brown and beige adipogenic differentiation. FASEB J. 2019 Apr;33(4):5300-5311.

    Takase R, Hino S, Nagaoka K, Anan K, Kohrogi K, Araki H, Hino Y, Sakamoto A, Nicholson TB, Chen T, Nakao M.

    Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treat ment: A prospective multicenter cohort study.Cancer Med. 2019 Mar 22. doi: 10.1002/cam4.2061.

    Nakano M, Koga H, Ide T, Kuromatsu R, Hashimoto S, Yatsuhashi H, Seike M, Higuchi N, Nakamuta M, Shakado S, Sakisaka S, Miuma S, Nakao K, Yoshimaru Y, Sasaki Y, Oeda S, Eguchi Y, Honma Y, Harada M, Nagata K, Mawatari S, Ido A, Maeshiro T, Matsumoto S, Takami Y, Sohda T, Torimura T.

    Advanced parametric imaging for evaluation of Crohn's disease using dual-energy computed tomography enterography. Radiol Case Rep. 2018 Apr 24;13(3):709-712.

    Taguchi N, Oda S, Kobayashi T, Naoe H, Sasaki Y, Imuta M, Nakaura T, Yamashita Y.

    Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study.Hepatol Int. 2019 Feb 28. doi: 10.1007/s12072-019-09939-2.

    Ide T, Koga H, Nakano M, Hashimoto S, Yatsuhashi H, Higuchi N, Nakamuta M, Oeda S, Eguchi Y, Shakado S, Sakisaka S, Yoshimaru Y, Sasaki Y, Honma Y, Harada M, Seike M, Maeshiro T, Miuma S, Nakao K, Mawatari S, Ido A, Nagata K, Matsumoto S, Takami Y, Sohda T, Kakuma T, Torimura T.

    Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma.Cancer Lett. 2019 Feb 12; 449:87-98.

    Nagaoka K, Bai X, Ogawa K, Dong X, Zhang S, Zhou Y, Carlson RI, Jiang ZG, Fuller S, Lebowitz MS, Ghanbari H, Wands JR.

    Chronic ethanol-mediated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine formation. FASEB J. 2019 Feb;33(2):1824-1835.

    Ji C, Nagaoka K, Zou J, Casulli S, Lu S, Cao KY, Zhang H, Iwagami Y, Carlson RI, Brooks K, Lawrence J, Mueller W, Wands JR, Huang CK.

    Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma. Surgery today 48(4) 431-438 2018

    Takeyama H, Beppu T, Higashi T, Kaida T, Arima K, Taki K, Imai K, Nitta H, Hayashi H, Nakagawa S, Okabe H, Hashimoto D, Chikamoto A, Ishiko T, Tanaka M, Sasaki Y, Baba H.

    Vonoprazan is superior to rabeprazole for healing endoscopic submucosal dissection induced ulcers.Digestion 97:170-176, 2018

    Yamasaki A, Yoshio T, Muramatsu Y, Horiuchi Y, Ishiyama A, Hirasawa T, Tsuchida T, Sasaki Y and Fujisaki J.

    The Incidence of Complications in Single-stage Endoscopic Stone Removal for Patients with Common Bile Duct Stones: A Propensity Score Analysis.Intern Med. 2018; 57(4): 469-477

    Saito H, Kadono Y, Kamikawa K, Urata A, Imamura H, Matsushita I, Kakuma T, Tada S.

    Usefullness and limitations of dual-layer spectral detector computed tomography for diagnosing biliary stones not detected by conventional computed tomography: a report of three cases.Clin J Gastroenterol. 2018; 11(2): 172-177

    Saito H, Noda K, Ogasawara K, Atsuji S, Takaoka H, Kajihara H, Nasu J, Morishita S, Matsushita I, Katahira K.

    Reduced iodinated contrast media for abdominal imaging by dual-layer spectral detector computed tomography for patients with kidney disease.Radiol Case Rep. 2018 13(2): 437-443

    Saito H, Noda K, Ogasawara K, Atsuji S, Takaoka H, Kajihara H, Nasu J, Kitaoka M, Morishita S, Matsushita I, Katahira K.

    Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma (SILIUS): a randomised, open label, phase 3 trial. The lancet. Gastroenterology & hepatology 3(6) 424-432 2018

    Kudo M, Ueshima K, Yokosuka O, Ogasawara S, Obi S, Izumi N, Aikata H, Nagano H, Hatano E, Sasaki Y, Hino K, Kumada T, Yamamoto K, Imai Y, Iwadou S, Ogawa C, Okusaka T, Kanai F, Akazawa K, Yoshimura KI, Johnson P, Arai Y, SILIUS study group.

    Analysis for the primary predictive factor for the incidence of esophageal injury after ablation of atrial fibrillation.J Cardiol. 2018 Dec;72(6):480-487.

    Ito M, Yamabe H, Koyama J, Kanazawa H, Kaneko S, Kanemaru Y, Kiyama T, Arima Y, Takashio S, Yamamoto E, Izumiya Y, Kojima S, Kaikita K, Shono T, Utsunomiya D, Sasaki Y, Yamashita Y, Tsujita K.

    Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.Drug Deliv. 2018 Nov;25(1):1067-1077.

    Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T.

    Spleen Dose-Volume Parameters as a Predictor of Treatment-related Lymphopenia During Definitive Chemoradiotherapy for Esophageal Cancer.In Vivo. 2018 Nov-Dec;32(6):1519-1525.

    Saito T, Toya R, Yoshida N, Shono T, Matsuyama T, Ninomura S, Watakabe T, Sasaki Y, Baba H, Oya N.

    Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. Oncol Lett. 2018 Oct;16(4):5275-5281.

    Ohuchi M, Sakamoto Y, Tokunaga R, Kiyozumi Y, Nakamura K, Izumi D, Kosumi K, Harada K, Kurashige J, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Shono T, Naoe H, Sasaki Y, Baba H.

    Impact of retroflexion in the right colon after repeated forward-view examination. JGH Open. 2018 Sep 10;2(6):282-287.

    Miyamoto H, Naoe H, Oda Y, Shono T, Narita R, Oyama S, Hashigo S, Okuda A, Hasuda K, Tanaka M, Sakurai K, Murakami Y, Sasaki Y.

    Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation.Cancer Lett. 2018 Aug 10; 429:1-10.

    Huang CK, Iwagami Y, Zou J, Casulli S, Lu S, Nagaoka K, Ji C, Ogawa K, Cao KY, Gao JS, Carlson RI, Wands JR.

    Usefulness of Virtual Touch Quantification for Staging Liver Fibrosis in Patients with Hepatitis C, and Factors Affecting Liver Stiffness Measurement Failure Compared with Liver Biopsy.Hepatol Res. Apr; 48(5):373-382, 2018

    Tsukano N, Miyase S, Saeki T, Mizobe K, Iwashita H, Arima N, Fujiyama S.

    Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma (SILIUS): a randomized, open label, phase 3 trial.The Lancet Gastroenterology Hepatology. 2018 Jun; 3(6): 424-432

    Kudo M, Ueshima K, Yokosuka O, Obi S, Izumi N, Aikata H, Nagano H, Hatano E, Sasaki Y, Hino K, Kumada T, Yamamoto K, Imai Y, Iwadou S, Ogawa C, Okusaka T, Kanai F, Akazawa K, Yoshimura K, Arai Y, the SILIUS study group.

    LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation.Nucleic Acids Res. 2018 Jun 20; 46(11):5441-5454.

    Anan K, Hino S, Shimizu N, Sakamoto A, Nagaoka K, Takase R, Kohrogi K, Araki H, Hino Y, Usuki S, Oki S, Tanaka H, Nakamura K, Endo F, Nakao M.

    Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status. CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):384-393.

    Oniki K, Watanabe T, Kudo M, Izuka T, Ono T, Matsuda K, Sakamoto Y, Nagaoka K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Saruwatari J.

    The glucocorticoid receptor regulates the ANGPTL4 gene in a CTCF-mediated chromatin context in human hepatic cells. PLoS One 12: e0169225, 2017.

    Nakamoto M, Ishihara K, Watanabe T, Hirosue A, Hino S, Shinohara M, Nakayama H, Nakao M.

    Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma.Heliyon. 2017 Sep 26;3(9): e00407.

    Iwagami Y, Casulli S, Nagaoka K, Kim M, Carlson RI, Ogawa K, Lebowitz MS, Fuller S, Biswas B, Stewart S, Dong X, Ghanbari H, Wands JR.

    Rb Loss and KRAS Mutation Are Predictors of the Response to Platinum-Based Chemotherapy in Pancreatic Neuroendocrine Neoplasm with Grade 3: A Japanese Multicenter Pancreatic NEN-G3 Study.Clin Cancer Res. 2017 Aug 15;23(16):4625-4632.

    Hijioka S, Hosoda W, Matsuo K, Ueno M, Furukawa M, Yoshitomi H, Kobayashi N, Ikeda M, Ito T, Nakamori S, Ishii H, Kodama Y, Morizane C, Okusaka T, Yanagimoto H, Notohara K, Taguchi H, Kitano M, Yane K, Maguchi H, Tsuchiya Y, Komoto I, Tanaka H, Tsuji A, Hashigo S, Kawaguchi Y, Mine T, Kanno A, Murohisa G, Miyabe K, Takagi T, Matayoshi N, Yoshida T, Hara K, Imamura M, Furuse J, Yatabe Y, Mizuno N.

    Outcomes of treatment with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation. Hepatology research: 47, 1147-1154 2017

    Honda M, Sugawara Y, Watanabe T, Tateyama M, Tanaka M, Uchida K, Kawabata S, Yoshii D, Miura K, Isono K, Hayashida S, Ohya Y, Yamamoto H, Sasaki Y, Inomata Y.

    A case of malignant peritoneal mesothelioma suggesting the utility of combining double-contrast radiography and endoscopy with computed tomography for diagnosis.Clin J Gastroenterol. 2017; 10(4): 371-376

    Saito H, Hasuda S, Nasu J, Kitaoka M, Matsushita I.

    E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLOS ONE 12, e0172509 2017 February 22, 2017

    Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H and Takeda K.

    Ledipasvir and sofosbuvir for recurrent hepatitis C after liver transplantation. Bioscience trends 10, 496-499 2017

    Oya Y, Sugawara Y, Watanabe T, Yoshimaru Y, Honda M, Hashimoto S, Yoshii D, Isono K, Hayashida S, Yamamoto H, Tanaka M, Sasaki Y, Inomata Y.

    Esophageal adenocarcinoma with enteroblastic differentiation arising in ectopic gastric mucosa in the cervical esophagus: a case report and literature review. J Gastrointestin Liver Dis 26; 193-197 2017

    Gushima R, Narita R, ShonoT, Naoe H, Yao T, Sasaki Y.

    Preoperative Diagnosis of Intestinal Endometriosis by Magnifying Colonoscopy and Target Biopsy.Case Rep Gastroenterology 11:494-499, 2017

    Tomiguchi J, Miyamoto H, Ozono K, Gushima R, Shono T, Naoe H, Tanaka M, Baba H, katabuchi H, Sasaki Y.

    Oral branched-chain amino acid granules improve structure and function of human serum albumin in liver cirrhotic patients. J Gastroenterol. ;52:754-765.2017

    Setoyama H, Tanaka M, Nagumo K, Naoe H, Watanabe T, Yoshimaru Y, Tateyama M, Sasaki M, Watanabe H, Otagiri M, Maruyama T, Sasaki Y.

    Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the gallbladder and review of the literature.BMJ Case Reports doi: 10.1136/bcr-2017-220161

    Honda M, Furuta Y, Naoe H, Sasaki Y.

    The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci USA 11, 3054-59, 2016.

    Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR.

    The longitudinal effect of the aldehyde dehydrogenase 2 *2 allele on the risk for non-alcoholic fatty liver disease. Nutrition & Diabetes 6, e210, 2016.

    Oniki K, Morita K, Watanabe T, Kajiwara A, Otake K, Nakagawa K, Sasaki Y, Ogata Y, Saruwatari J.

    Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients.Journal of Gastroenterology 52(6) 754-765 2016

    Setoyama H, Tanaka M, Nagumo K, Naoe H, Watanabe T, Yoshimaru Y, Tateyama M, Sasaki M, Watanabe H, Otagiri M, Maruyama T, Sasaki Y.

    Incidence and risk factors of synchronous colorectal cancer in patients with esophageal cancer: an analysis of 480 consecutive colonoscopies before surgery.International journal of clinical oncology 21(6) 1079-1084 2016

    Yoshida N, Tamaoki Y, Baba Y, Sakamoto Y, Miyamoto Y, Iwatsuki M, Shono T, Miyamoto H, Imuta M, Kurashige J, Sawayama H, Tokunaga R, Watanabe M, Sasaki Y, Yamashita Y, Baba H.

    Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma.Virchows Archiv: an international journal of pathology 468(2) 169-177 2016

    Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Yao K, Sasaki Y.

    Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.Cancer Resarch 7: 1445-56, 2015.

    Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, and Nakao M.

    Polythiol-Containing, Recombinant Mannosylated-Albumin Is a Superior CD68+/CD206+ Kupffer Cell -Targeted Nanoantioxidant for Treatment of Two Acute Hepatitis Models. Journal of Pharmacological Experiment & Therapy 352: 244-257, 2015.

    Maeda H, Hirata K, Watanabe H, Ishima Y, Victor Tuan Giam Chuang, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, and Maruyama T.

    Carbohydrate antigen 19-9 is a useful prognosis marker in esophagogastric junction adenocarcinoma.Cancer Medicine 4:1659-1966, 2015.

    Tokunaga R, Imamura Y, Nakamura K, Uchihara T, Ishimoto T, Nakagawa S, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Oyama S, Shono T, Naoe H, Saeki H, Oki E, Watanabe M, Sasaki Y, Maehara Y, Baba H.

    A rare case showing subacute thyroiditis -like symptoms with amyloid goiter after anti-TNF therapy. Endocrinology, Diabetes and Metabolism Case Reports.Epub May 1, 2015.

    Kawashima J, Naoe H, Sasaki Y, Araki E.

    Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.Molecular and cellular biology 35(7) 1068-1080 2015

    Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y, Nakao M.

    Evaluation of sorafenib treatment and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: a comparative study using the propensity score matching method.Cancer Medicine 4: 1214-1223, 2015.

    Fukubayashi K, Tanaka M, Izumi K, Watanabe T, Fujie S, Kawasaki T, Yoshimaru Y, Tateyama M, Setoyama H, Naoe H, Kikuchi K, and Sasaki Y

    Clinical impact of preoperative endoscopic ultrasound-guided fine needle aspiration for pancreatic ductal adenocarcinoma.Endoscopic Ultrasound 5(2) 94-100, 2015.

    Tsutsumi H, Hara K, Mizuno N, Hijioka S, Imaoka H, Tajika M, Tanaka T, Ishihara M, Yoshimura K, Shimizu Y, Niwa Y, Sasaki Y, Yamao K

    Development and Validation of a Symptom Scale Specific for Ascites Accompanied with CirrhosisClinical and translational gastroenterology 5 e48 2014

    Onishi Y, Wakita T, Fukuhara S, Noguchi Y, Okada M, Sakaida I, Sasaki Y, Kobayashi K.

    Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases.PLOS ONE 9: e85216, 2014

    Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.

    Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells. Stem Cell Res. 2014 Jan 27;12 (2):574-583

    Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, Ando Y.

    VMAT2 identified as a regulator of late-stage β-cell differentiation. Nat Chem Biol. 2014 Feb;10(2):141-8

    Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S.

    Hepatic differentiation from murine and human iPS cells using nanofiber scaffolds. Methods Mol Biol. 2014 Nov; (Epub ahead of print)

    Yamazoe T, Shiraki N, Kume S,

    Clinicopathological differences of laterally spreading tumors arising in the colon and rectum. Int J Colorectal Dis. 29(9): 1069-1075, 2014

    Miyamoto H, Ikematsu H, Fujii S, Osera S, Odagaki T, Oono Y, Yano T, Ochiai A, Sasaki Y, Kaneko K.

    Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells. Molecular and cellular biology 35(7) 1068-1080 2015

    Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y and Nakao M.

    Cys34-cysteinylated human serum albmin is a sensitive plasma marker in oxidative stress-related chronic disease. PLOS ONE 9: e85216, 2014

    Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.

    Morphological change of a laterally spreading rectal tumor over a short period. BMC Gastroenterology 19;13:129, 2013

    Miyamoto H, Oono Y, KL F, Ikematsu H, Fujii S, Kojima T, Yano T, Ochiai A, Sasaki Y, Kaneko K.

    Pancreatic metastasis from mixed adenoneuroendocrine carcinoma of the uterine cervix: a case report. Case Rep Oncol 6: 256-262, 2013

    Nishimura C, Naoe H, Hashigo S, Tsutsumi H, Ishii S, Konoe T, Watanabe T, Shono T, Sakurai K, Takahashi K, Ikuta Y, Chikamoto A, Tanaka M, Iyama K, Baba H, Katabuchi H, Sasaki Y.

    VMAT2 identified as a regulator of late-stage β-cell differentiation. Nat Chem Biol Dec 15 doi:10.1038/nchembio.1410, 2013

    Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S.

    A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. J Cell Sci 1: 126, 5391-5399, 2013

    Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S.

    Electrocautery therapy combined with oral steroid administration for refractory corrosive esophageal stenosis prevents restenosis. Esophagus 10: 230-234, 2013

    Nonaka K, Ban S, Aikawa M, Yamasaki A, Okuda A, Kounoe T, Naoe H, Sakurai K, Miyazawa M, Kita H, Sasaki Y.

    Alubumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation. Stem Cell Res 10: 19-194, 2013

    Umeda K, Suzuki K, Yamazoe T, Shiraki N, Higuchi Y, Tokieda K, Kume K, Mitani K, Kume S.

    Relation between bile acid reflux into stomach and the risk of atrophic gastritis and intestinal metaplasia: a multicenter study of 2283 cases. Dig Endosc 25: 519-525, 2013

    Matsuhisa T, Arakawa T, Watanabe T, Tokutomi T, Sakurai K, Okamura S, Chono S, Kamada T, Sugiyama A, Fujimura Y, Matsuzawa K, Ito M, Yasuda M, Ota H, Haruma K.

    Narrow band imaging of adenocarcinoma arising from ectopic gastric mucosa in the upper esophagus. Endoscopy 45, 2013

    Nonaka K, Watanabe M, Yuruki H, Okuda A, Sakuari K, Iyama K, Sasaki Y.

    Metabolism-epigenome crosstalk in physiology and diseases. J Hum Genet 58: 410-415, 2013

    Hino S, Nagaoka K, Nakao M.

    The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells. Biochem Biophys Res Commun 430:757-762, 2013

    Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S.

    Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, Phase II study. J Gastroenterol 47, 1342-1351, 2012

    Kawaguchi T, Komori A, Seike M, Fujiyama S, Watanabe H, Tanaka M, Sakisaka S, Nakamuta M, Sasaki Y, Oketani M, Hattori T, Katsura K, Sata M.

    A case of gastric musosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis. World J Gastrointest Endosc 16: 151-156, 2012

    Nonaka K, Ishikawa K, Arai S, Nakao M, Shimizu M, Sakurai T, Nagata K, Nishimura M, Togawa O, Ochiai Y, Sasaki Y, Kita H.

    Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells. Aging Cell 11: 553-556, 2012

    Hirosue A, Ishihara K, Tokunaga K, Watanabe T Saitoh N, Nakamoto M, Chandra T, Narita M, Shinohara M and Nakao M.

    Higher-order chromatin regulation and differential gene expression in human Tumor necrosis factor / Lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol 32: 1529-1541, 2012

    Watanabe T, Ishihara K, Hirosue A, Watanabe S, Hino S, Ojima H, Kanai Y, Sasaki Y, and Nakao M.

    Primary hepatic gastrinoma as an unusual manifestation of Zollinger-Ellison syndrome. Case Reports in Gastroenterology 6:590-595, 2012

    Naoe H, Iwasaki H, Kawasaki T, Ozaki T, Tsutsumi H, Okuda A, Konoe T, Nonaka K, Kaku E, Shono T, Yokomine k, Sakurai K, Iyama K, Hirota M, Sasaki Y.

    LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol 28; 197, 625-641, 2012

    Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihara Y, Saya H, Kuninaka S.

    FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun 27: 758, 1-12, 2012

    Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, Nakao M.

    Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS). BMC Gastroenterol 1; 12:42, 2012

    Sakurai K, Nagahara A, Inoue K, Akiyama J, Mabe K, Suzuki J, Habu Y, Araki A, Suzuki T, Satoh K, Nagami H, Harada R, Tano N, Kusaka M, Fujioka Y, Fujimura T, Shigeto N, Oumi T, Miwa J, Miwa H, Fujimoto K, Kinoshita Y, Haruma K.

    Endoscopic diagnosis and treatment of superficial colorectal neoplasm. Curr Res Cancer 6: 27-41, 2012

    Shono T, Nonaka K, Ochiai Y, Nakao M, Togawa O, Nishimura M, Ishikawa K, Arai S, Sakurai K, Sasaki Y and Kita H.

    The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol 30; 3994-4005, 2010

    Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H and Kuninaka S.

    Chronic hepatitis C viral infection reduced NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.Biochem Biophys Res Commun 393: 331-337, 2010

    Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y and Okada S.

    Magnifying endoscopic observation of mantle cell lymphoma in the stomach using the narrow-band imaging systemEndoscopy 42: E94-95, 2010

    Nonaka K, Ishikawa K, Arai S, Shimizu M, Sakurai T, Nishimura M, Nakao M, Sasaki Y and Kita H.

    Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms.World J Gastrointest Endosc 2: 69-74, 2010

    Nonaka K, Arai S, Ishikawa K, Nakao M, Nakai Y, Togawa O, Nagata K, Shimizu M, Sasaki Y and Kita H.

    Transcatheter arterial infusion chemotherapy with cisplatin-lipiodol suspension in patients with hepatocellular carcinoma.J Gastroenterol 45: 60-67, 2010

    Ikeda M, Maeda S, Ashihara H, Nagahama H, Tanaka M and Sasaki Y.

    The Forkhead Box M1 transcriptional factor as a possible immunotherapeutic tumor-associated antigen.Int J Cancer 126: 2153-2163, 2009

    Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y and Nishimura Y.

    Effects of oral administered S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.Ther. Drug. Monit 31: 400-403, 2009

    Yokoo, K., Hamada, A., Tazoe, K., Sasaki, Y. and Saito, H.

    Identification of the H2-Kd-restricted CTL epitopes of a tumor-associated antigen, SPARC, which can stimulate antitumor immunity without causing autoimmune disease in mice. Cancer Sci 100: 132-137, 2009

    Ikuta, Y.,* Hayashida, Y.*, Hirata, Irie, A., Senju, S., Nakatsura, T., Monji, M., Sasaki, Y., Baba, H. and Nishimura, Y. (*These two authors contributed equally.)

    Identification of the major antigenic protein of helicobacter cinaedi and the immunogenicity during infections in humans.Clinical and Vaccine Immunology 15: 513-521, 2008

    Iwashita, H., Fujii, S., Kawamura, Y., Okamoto, T., Sawa, T., Masaki, T., Nishizono, A., Higashi, S., Kitamura, T., Tamura, F., Sasaki, Y. and Akaike, T.

    Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.Oncogene 26: 2395-2406, 2007

    Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H.

    Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in ApcMin/+ mice. Cancer Sci 98: 1930-35, 2007

    Yokomine, K., Nakatsura, T., Senju, S., NAkagata, N., Minohara, M., Kira , J., Motomura, Y., Kubo, T., Sasaki, Y. and Nishimura, Y.

    Does oxidative stress participate in the development of hepatocellular carcinoma?J Gastroenterol 41: 1135-48, 2006

    Sasaki, Y.

    Proportion of de novo cancers among colorectal cancers in Japan.Gastroenterology 131: 40-46, 2006

    Goto, H., Oda, Y., Murakami, Y., Tanaka, T., Hasuda, K., Goto, S., Sasaki, Y. Sakisaka, S. and Hattori, M.

    Immunization with heat shock protein 105-pulsed dendritic cells leads to tumor rejection in mice.Biochem. Biophys. Res. Commun 343: 269-278, 2006

    Yokomine, K., Nakatsura, T., Monohara, M., Kira, J., Kubo, T., Sasaki, Y. and Nishimura, Y.

    Pharmacokinetic changes of irinotecan by interstitial alkalinization in an advanced colorectal cancer patient. Ther. Drug. Monit 27: 536-538, 2005

    Hamada, A., Aoki, A., Terazaki, H., Ito, K., Yokoo, K., Sasaki, Y. and Saito, H.

    Alteration in gene expression profile by full length hepatitis B virus genome.Intervirology 48: 77-83, 2005

    Nakanishi, F., Ohkawa, K., Ishida, H., Housui, A., Sato, A., Hiramatsu, N., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M., and Hayashi, N.

    Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.Anat Embryol 208: 145-150, 2004

    Yoshida K, Nakayama K, Kase S, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nishi S, Nakayama KI.

    Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.GraefesArch Clin Exp Ophthalmol 242: 437-441, 2004

    Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nakayama KI.

    Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis.Dev Cell 6: 661-672, 2004

    Nakayama K*, Nagahama H*, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI. (*These authors contributed equally to this work.)

    Involvement of p27(KIP1) in the Proliferation of the Developing Corneal Endothelium.Invest Ophthalmol Vis Sci 45: 2163-2167, 2004

    Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Nishi S, Nakayama KI.

    Ninjurin increases p21 expression and induces cellular senescence in human hepatoma cells. J. Hepatol 41: 637-643, 2004.

    Toyama, T., Sasaki, Y., Horimoto, M., Iyoda, K., Yakushijin, T., Ohkawa, K., Takehara, T., Kasahara, A., Araki, T., Hori, M., and Hayashi, N.

    Assessment of adverse reactions and pharmacokinetics of ribavirin in combination with interferon α-2b in patients with chronic hepatitis C.Drug Metabol. Pharmacokin 19: 438-443, 2004.

    Uchida, M., Hamada, A., Yamasaki, M., Fujiyama, S., Sasaki, Y., and Saito, H.

    Interferon therapy for aged patients with chronic hepatitis C: improved survival in patients exhibiting a biochemical response.J. Gastroenterol 39: 1069-1077, 2004

    Imai, Y., Kasahara, A., Tanaka, H., Okanoue, T., Hiramatsu, N., Tsubouchi, H., Yoshioka, K., Kawata, S., Tanaka, E., Hino, K., Hayashi, K., Tamura, S., Itoh, Y., Sasaki, Y., Kiyosawa, K., Kakumu, S., Okita, K., and Hayashi, N.

    A different amyloid formation mechanism: de novo oculoeptomeningeal amyloid deposits after liver transplantation. Transplantation 77: 345-349, 2004.

    Ando, Y., Terazaki, H., Nakamura, M., Ando, E., Haraoka, K., Yamashita, T., Ueda, M., Okabe, H., Sasaki, Y., Tanihara, H., Uchino, M., and Inomata, Y.

    A novel tool for detecting amyloid deposits in systemic amyloidosis in vitro and in vivo.Lab. Invest 83: 1751-1759, 2003.

    Ando, Y., Haraoka, K., Terazaki, H., Tanoue, Y., Ishikawa, K., Katsuragi, S., Nakamura, M., Sun, X., Nakagawa, K., Sasamoto, K., Takesako, K., Ishizaki, T., Sasaki, Y., and Doh-ura, K.

    Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.Cancer Res 63: 6726-34, 2003.

    Yasumaru, M., Tsuji, S., Tsujii, M., Irie T., Komori, M., Kimura, A., Nishida T., Kakiuchi, Y, Kawai, N., Murata H., Horimoto M., Sasaki, Y., Hayashi, N., Kawano, S., and Hori, M.:

    CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver.Int. J. Cancer 106: 81-89, 2003.

    Miyagi, T., Takehara, T., Tatsumi, T., Kanto, T., Suzuki, T., Jinushi, M., Sugimoto, K., Sasaki, Y. Hori, M. and Hayashi N.

    Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-gamma stimuli.J. Biol. Chem 278: 28562-28571, 2003.

    Housui, A., Ohkawa, K., Ishida, H., Sato, A., Nakanishi, F., Ueda, K., Takahara, T., kasahara, A., Sasaki, Y., Hori, M. and Hayashi, N.

    Involvement of the p38 mitogen-activated protein kinase cascade in human hepatocellular carcinoma. Cancer 97: 3017-3026, 2003

    Iyoda, K., Sasaki, Y., Horimoto, M., Toyama, T., Yakushijin, T., Sakakibara, M., Takehara, T., Fujimoto, J., Hori, M., Wands, JR. and Hayashi, N.

    Molecular pathogenesis of viral hepatitis.Inter. Med 42: 290-291, 2003

    Hayashi, N., Kanto, T., Housui, A., Sugimoto, K., Ohkawa, K., Takehara, T.and Sasaki, Y.

    Development of colitis in signal transducers and activators of transcription 6-deficient T cell recedptor α-deficient mice; A potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ ββT cells.Am. J. Pathology 162: 263-271, 2003

    Okuda, Y., Takahashi, I., Kim, J.K., Ohta, N., Iwatani, Iijima, H., Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M.N., Kawano, S., Takeda, K., Akira, S., Sasaki, Y., Hori, M. and Kiyono, H.

    Changes in gene expression profile by HCV core protein in cultures liver cells: analysis by DNA array assay.Hepatol. Res 25: 396-408, 2003

    Ohkawa, K., Ishida, H., Nakanishi, F., Housui, A., Sato, A., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M and Hayashi, N.

    Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.Int. J. Cancer 104: 354-361, 2003

    Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Groh, V., Spies, T., Kimura, R., Miyagi, T., Mochizuki, K., Sasaki, Y. and Hayashi N.

    Intravenous injection of naked plasmid DNA encoding hepatitis B virus (HBV) produces HBV and induces humoral immune response in mice.Biochem. Biophys. Res. Commun 300: 784-788, 2003

    Suzuki, T., Takehara, T., Ohkawa, K., Ishida, H., Jinushi, M., Miyagi, T., Sasaki, Y. and Hayashi, N.

    Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.J. Gastroenterol. Hepatol 18: 32-40, 2003

    Miyagi, T., Tatsumi, T., Takehara, T., Kanto, T., Kuzushita, N., Sugimoto, K., Jinushi, M., Kasahara, A., Sasaki, Y. Hori, M. and Hayashi, N.

    Critical role of MICA/B expression on interferon α-stimutaled dendritic cells in NK cell activation: Impairment in chronic hepatitis C virus infection.J. Immunol 170: 1249-1256, 2003

    Jinushi, M., Takehara, T., Kanto, T., Tatsumi, T., Groh, V., Spies, T., Miyagi, T., Suzuki, T., Sasaki, Y. and Hayashi N.


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